Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3–IR and GM1–TrkA interactions
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14532
Abstract: The interactions between gangliosides and proteins belonging to the same or different lipid domains and their influence on physiological and pathological states have been analysed in detail. A well‐known factor impacting on lipid–protein interactions and… read more here.
Keywords: gm1 trka; signal transduction; gm1; regulation signal ... See more keywords
Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
Sign Up to like & getrecommendations! Published in 2020 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-020-09919-x
Abstract: It has been recently reported by our group that GM1-oligosaccharide added to neuroblastoma cells or administered to mouse experimental model mimics the neurotrophic and neuroprotective properties of GM1 ganglioside. In addition to this, differently from… read more here.
Keywords: gm1; role gm1; differentiation; gm1 oligosaccharide ... See more keywords
The Neuroprotective Role of the GM1 Oligosaccharide, II3Neu5Ac-Gg4, in Neuroblastoma Cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1556-8
Abstract: Recently, we demonstrated that the GM1 oligosaccharide, II3Neu5Ac-Gg4 (OligoGM1), administered to cultured murine Neuro2a neuroblastoma cells interacts with the NGF receptor TrkA, leading to the activation of the ERK1/2 downstream pathway and to cell differentiation.… read more here.
Keywords: ii3neu5ac gg4; gm1; gm1 oligosaccharide; oligosaccharide ii3neu5ac ... See more keywords
Protective Effect of GM1 Attenuates Hippocampus and Cortex Apoptosis After Ketamine Exposure in Neonatal Rat via PI3K/AKT/GSK3β Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02346-5
Abstract: Ketamine is a widely used analgesic and anesthetic in obstetrics and pediatrics. Ketamine is known to promote neuronal death and cognitive dysfunction in the brains of humans and animals during development. Monosialotetrahexosyl ganglioside (GM1), a… read more here.
Keywords: apoptosis; ketamine; gm1; gsk3 pathway ... See more keywords
Non-enzymatic oxidation of ganglioside studied by mass spectrometry: Gm1 as a case study
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.391
Abstract: Gangliosides are acidic glycosphingolipids (GLS) found in cells membrane, lipid raft domains, and are particularly abundant in central nervous systems, where they play important roles. Alteration in gangliosides has been correlated with the development of… read more here.
Keywords: oxidation gm1; oxidation; study; gm1 ... See more keywords
Recombination between 13C and 2H to Form Acetylide (13C22H-) Probes' Nanoscale Interactions in Lipid Bilayers via Dynamic Secondary Ion Mass Spectrometry: Cholesterol and GM1 Clustering.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01336
Abstract: Although it is thought that there is lateral heterogeneity of lipid and protein components within biological membranes, probing this heterogeneity has proven challenging. The difficulty in such experiments is due to both the small length… read more here.
Keywords: secondary ion; mass spectrometry; recombination; gm1 ... See more keywords
First radiolabeling of a ganglioside with a positron emitting radionuclide - in vivo PET demonstrates low exposure of radiofluorinated GM1 in non-human primate brain.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00161
Abstract: Gangliosides are biologically important glycolipids widely distributed in vertebrate cells. An important member of the ganglioside family is the monosialylganglioside GM1, which has been suggested as a potential therapeutic for Parkinson's disease. In the current… read more here.
Keywords: pet; gm1; ganglioside positron; first radiolabeling ... See more keywords
Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-02179-0
Abstract: Cholera is a life-threatening disease in many countries, and new drugs are clearly needed. C-glycosidic antagonists may serve such a purpose. Here we report atomic-resolution crystal structures of three such compounds in complexes with the… read more here.
Keywords: towards new; crystal structures; gm1; new cholera ... See more keywords
Antitumor Immunotherapy of Sialic Acid and/or GM1 Modified Coenzyme Q10 Submicron Emulsion
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02426-2
Abstract: Immunotherapy is a novel therapeutic approach for controlling and killing tumor cells by stimulating or reconstituting the immune system, among which T cells serve as immune targets. Herein, we used coenzyme Q10 (CoQ10), which has… read more here.
Keywords: immunotherapy; submicron emulsion; gm1; tumor ... See more keywords
Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4141761
Abstract: Ganglioside GM1 is a glycosphingolipid found on mammalian cell membranes, and it is involved in ischemic encephalopathy, spinal cord injury and neurodegenerative diseases. Fatty acids, as a structure module of GM1, have been reported to… read more here.
Keywords: ganglioside gm1; gm1 derivatives; activity; neurite outgrowth ... See more keywords
Gangliosides: Treatment Avenues in Neurodegenerative Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00859
Abstract: Gangliosides are cell membrane components, most abundantly in the central nervous system (CNS) where they exert among others neuro-protective and -restorative functions. Clinical development of ganglioside replacement therapy for several neurodegenerative diseases was impeded by… read more here.
Keywords: treatment avenues; avenues neurodegenerative; gangliosides treatment; disease ... See more keywords