Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0454-y
Abstract: GM1 ganglioside is particularly abundant in the mammalian central nervous system and has shown beneficial effects on neurodegenerative diseases. In this study, we investigated the therapeutic effect of GM1 ganglioside in experimental models of Parkinson’s… read more here.
Keywords: autophagy dependent; ganglioside; gm1 ganglioside; syn a53t ... See more keywords
GM1 ganglioside-independent intoxication by Cholera toxin
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DOI: 10.1371/journal.ppat.1006862
Abstract: Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors via its B subunit (CTB). We have recently shown that in addition to the previously described binding partner ganglioside GM1, CTB binds… read more here.
Keywords: cholera; gm1 ganglioside; cholera toxin; intoxication ... See more keywords
Anti-Inflammatory Effects of GM1 Ganglioside on Endotoxin-Induced Uveitis in Rats
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DOI: 10.3390/biom12050727
Abstract: Exogenous ganglioside GM1 has been reported to exert an immunomodulatory effect. We investigated the anti-inflammatory effect of GM1 ganglioside on endotoxin-induced uveitis (EIU) in rats and RAW 264.7 macrophages. Methods: EIU was induced in Lewis… read more here.
Keywords: effect; gm1 ganglioside; anti inflammatory; ganglioside endotoxin ... See more keywords