A combined NMR, MD and DFT conformational analysis of 9-O-acetyl sialic acid-containing GM3 ganglioside glycan and its 9-N-acetyl mimic.
Sign Up to like & getrecommendations! Published in 2020 at "Glycobiology"
DOI: 10.1093/glycob/cwaa040
Abstract: O-Acetylation of carbohydrates such as sialic acids is common in nature, but its role is not clearly understood due to the lability of such O-acetyl group. We demonstrated previously that 9-acetamido-9-deoxy-N-acetylneuraminic acid (Neu5Ac9NAc) is a… read more here.
Keywords: containing gm3; gm3 ganglioside; acetyl; ganglioside glycan ... See more keywords
Pathophysiological Significance of GM3 Ganglioside Molecular Species With a Particular Attention to the Metabolic Syndrome Focusing on Toll-Like Receptor 4 Binding
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.918346
Abstract: GM3 ganglioside, the first molecule in ganglioside family biosynthesis, is formed by transfer of sialic acid to lactosylceramide. Several dozen GM3 molecular species exist, based on diversity of ceramide structures. Among ceramide structures composed of… read more here.
Keywords: toll like; gm3; gm3 ganglioside; metabolic syndrome ... See more keywords