Abstract LB164: A novel glycomimetic compound (GMI-1757) with dual functional antagonism to E-selectin and galectin-3 attenuates fibrosis, facilitates mononuclear cell infiltration and optimizes anti-PD-L1 therapeutic activity in a pancreatic adenocarcinoma model
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DOI: 10.1158/1538-7445.am2021-lb164
Abstract: The inability to generate robust anti-tumor responses with therapeutics affecting T cell function has been ascribed to multiple parameters such as the tumor fibrotic compartment and the degree/makeup of host infiltrative cells. These parameters are… read more here.
Keywords: gmi; gmi 1757; fibrosis; infiltration ... See more keywords