KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13719
Abstract: Intraductal papillary mucinous neoplasms (IPMNs) are potential precursor lesions of pancreatic cancer. We assessed the efficacy of screening for KRAS proto‐oncogene, GTPase (KRAS), and GNAS complex locus (GNAS) mutations in cell‐free DNA (cfDNA)—using digital droplet… read more here.
Keywords: gnas mutations; kras gnas; papillary mucinous; mucinous neoplasms ... See more keywords
Activating KRAS and GNAS mutations in heterotopic submucosal glands of the stomach
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DOI: 10.1007/s00535-022-01863-x
Abstract: The heterotopic submucosal gland (HSG) is a common incidental finding in gastrectomy specimens. The majority of HSGs are small incidental lesions, which are also known as gastritis cystica profunda. However, larger lesions may appear as… read more here.
Keywords: hsg lesions; activating kras; mutations heterotopic; kras gnas ... See more keywords
KRAS Mutations With No GNAS Mutations in an Intraductal Papillary Mucinous Neoplasm: Are There Common Pathways With Pancreatic Ductal Adenocarcinoma? Lessons From an Extended IPMN, Covering the Entire Pancreas.
Sign Up to like & getrecommendations! Published in 2017 at "Pancreas"
DOI: 10.1097/mpa.0000000000000688
Abstract: endothelium efficiently endocytosed stabilin ligand (Formaldehyde-treated boivine serum albumin [FT-BSA]) (not shown), whereas only few cells in mouse pancreatic islets endocytosed the ligand (Fig. 1B). NODmice did not have insulitis inmost islets, but neither immune… read more here.
Keywords: pancreas kras; mutations intraductal; gnas mutations; kras mutations ... See more keywords
Molecular Characterization of Pancreatic Simple Mucinous Cysts with GNAS Mutation: A Case Report and Literature Review.
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DOI: 10.1097/mpa.0000000000002535
Abstract: OBJECTIVES Pancreatic simple mucinous cysts (SMCs) are characterized by cystic lesions>1 cm in size, lacking ovarian-type stroma and lined by a single layer of bland epithelium. Although SMCs are typically considered benign, sporadic cases with KRAS… read more here.
Keywords: simple mucinous; gnas mutations; report; mucinous cysts ... See more keywords
Prognostic implications and therapeutic response in GNAS-mutated colorectal adenocarcinoma: A retrospective cohort analysis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.4_suppl.244
Abstract: 244 Background: GNAS, a key regulator of the G-protein signaling pathway, is frequently mutated in colorectal adenocarcinomas and other malignancies. Despite its role in tumorigenesis, GNAS mutations remain understudied, with no established targeted therapies. Exploring… read more here.
Keywords: gnas mutations; disease; response; therapeutic response ... See more keywords
GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma
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DOI: 10.32604/or.2024.046007
Abstract: Approximately 30%–40% of growth hormone–secreting pituitary adenomas (GHPAs) harbor somatic activating mutations in GNAS (α subunit of stimulatory G protein). Mutations in GNAS are associated with clinical features of smaller and less invasive tumors. However,… read more here.
Keywords: gnas mutations; ghpas; cell invasion; cell ... See more keywords
The prevalence, diagnostic accuracy and genotype-phenotype correlation of GNAS mutations in fibrous dysplasia: a meta-analysis
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DOI: 10.3389/fgene.2024.1377716
Abstract: Background There is inconsistent evidence regarding the accuracy of GNAS mutations identification for the diagnosis of FD/MAS. This study was performed to estimate the prevalence and diagnostic accuracy of GNAS mutations detection and to preliminarily… read more here.
Keywords: gnas mutations; genotype phenotype; accuracy; diagnostic accuracy ... See more keywords