Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.
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DOI: 10.1021/acs.jmedchem.9b00339
Abstract: Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations.… read more here.
Keywords: latency; gnidimacrin derivatives; activity relationship; structure activity ... See more keywords