GnRH neurogenesis depends on embryonic pheromone receptor expression
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111030
Abstract: Gonadotropin-releasing hormone (GnRH) neurons control mammalian reproduction and migrate from their birthplace in the nasal placode to the hypothalamus during development. Despite much work on the origin and migration of GnRH neurons, the processes that… read more here.
Keywords: gnrh; gnrh neurons; receptor expression; gnrh neurogenesis ... See more keywords
Arcuate Kisspeptin Neurons Coordinate Reproductive Activities with Metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in reproductive medicine"
DOI: 10.1055/s-0039-3400251
Abstract: Hypothalamic control of fertility is the quintessential homeostatic function. However, fertility is metabolically demanding; so, there must be coordination between energy states and reproductive functions. Because gonadotropin-releasing hormone (GnRH) neurons are devoid of many of… read more here.
Keywords: hormone; energy; gnrh neurons; kisspeptin neurons ... See more keywords
Deciphering the Transcriptional Landscape of Human Pluripotent Stem Cell-Derived GnRH Neurons: The Role of Wnt Signaling in Patterning the Neural Fate
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells"
DOI: 10.1093/stmcls/sxac069
Abstract: Abstract Hypothalamic gonadotropin-releasing hormone (GnRH) neurons lay the foundation for human development and reproduction; however, the critical cell populations and the entangled mechanisms underlying the development of human GnRH neurons remain poorly understood. Here, by… read more here.
Keywords: cell; human pluripotent; differentiation; gnrh neurons ... See more keywords
Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13110
Abstract: Polycystic ovary syndrome (PCOS) is associated with androgen excess and, frequently, hyperactive pulsatile luteinizing hormone (LH) secretion. Although the origins of PCOS are unclear, evidence from pre‐clinical models implicates androgen signalling in the brain in… read more here.
Keywords: gnrh neurons; androgen excess; female mice; dht ... See more keywords
Sex on the Brain: Reproductive Comorbidities in Temporal Lobe Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221135717
Abstract: Increased GABA Transmission to GnRH Neurons After Intrahippocampal Kainic Acid Injection in Mice Is Sex-Specific and Associated With Estrous Cycle Disruption Ingram RJ, Leverton LK, Daniels VC, Li J, Christian-Hinman CA. Neurobiol Dis. 2022;172:105822. doi:10.1016/j.nbd.2022.105822… read more here.
Keywords: temporal lobe; sex; ihka females; epilepsy ... See more keywords
Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse
Sign Up to like & getrecommendations! Published in 2017 at "Endocrinology"
DOI: 10.1210/en.2016-1807
Abstract: The tachykinins substance P (SP) and neurokinin A (Tac1) have emerged as novel regulators of kisspeptin/GnRH release. Recently, we documented that SP modulates reproductive function in the female mouse. Here, we extended this characterization to… read more here.
Keywords: male mouse; gnrh neurons; receptor; gnrh ... See more keywords
Identification of Genes Enriched in GnRH Neurons by Translating Ribosome Affinity Purification and RNAseq in Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00001
Abstract: Gonadotropin-releasing hormone (GnRH) neurons are a nexus of fertility regulation. We used translating ribosome affinity purification coupled with RNA sequencing to examine messenger RNAs of GnRH neurons in adult intact and gonadectomized (GDX) male and… read more here.
Keywords: ribosome affinity; gnrh neurons; translating ribosome; mice ... See more keywords
Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00435
Abstract: A subpopulation of neurons located within the arcuate nucleus, colocalizing kisspeptin, neurokinin B, and dynorphin (Dyn; termed KNDy neurons), represents key mediators of pulsatile GnRH secretion. The KNDy model of GnRH pulse generation proposes that… read more here.
Keywords: gnrh neurons; kndy gnrh; dyn; pulse termination ... See more keywords
A CRH receptor type 1 agonist increases GABA transmission to GnRH neurons in a circulating-estradiol-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology"
DOI: 10.1210/endocr/bqaa140
Abstract: GnRH neurons are central regulators of reproduction and respond to factors affecting fertility, such as stress. Corticotropin-releasing hormone (CRH) is released during stress response. In brain slices from unstressed controls, CRH has opposite, estradiol-dependent, effects… read more here.
Keywords: crh receptor; gnrh neurons; circulating estradiol; estradiol dependent ... See more keywords
SAT-413 Examining Alterations to Arcuate Nucleus NPY Neurons and Their Neural Projections in a Mouse Model of PCOS
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-413
Abstract: Abstract Polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility, is associated with a breakdown in signaling within the hormone sensitive neural network that regulates gonadotropin-releasing hormone (GnRH) neurons, ultimately increasing GnRH neural… read more here.
Keywords: arcuate nucleus; npy neurons; pcos; gnrh neurons ... See more keywords
SAT-423 The Involvement of GnRH Neurons in Mediating the Effects of RFRP-3 on the Mouse Reproductive Axis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-423
Abstract: Abstract In 2000, gonadotrophin-inhibitory hormone was discovered in birds and shown to inhibit gonadotrophin secretion. The mammalian ortholog was concurrently discovered in humans and rats and termed RFamide-related peptide-3 (RFRP-3). Recent results have shown that… read more here.
Keywords: mice; rfrp; gnrh; gnrh neurons ... See more keywords