Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60837-8
Abstract: Brainstem noradrenaline (NA) neurons modulate the activity of many neural networks including those responsible for the control of fertility. Using brain slice electrophysiology, we demonstrate that the arcuate nucleus kisspeptin (ARNKISS) neurons, recently identified to… read more here.
Keywords: gnrh pulse; brainstem; pulse generator; kisspeptin ... See more keywords
In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117767119
Abstract: Significance Hypothalamic oscillators that generate pulsatile patterns of hormone secretion represent a fundamental physiological feature regulating homeostatic systems. How individual cells within these neural ensembles generate and coordinate episodic activity and resultant pulse secretion is… read more here.
Keywords: gnrh; gnrh pulse; generator; temporal order ... See more keywords
Neuronal network dynamics in the posterodorsal amygdala: shaping reproductive hormone pulsatility
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2024.0143
Abstract: Normal reproductive function and fertility rely on the rhythmic secretion of gonadotropin-releasing hormone (GnRH), which is driven by the hypothalamic GnRH pulse generator. A key regulator of the GnRH pulse generator is the posterodorsal subnucleus… read more here.
Keywords: gnrh pulse; pulse generator; generator activity; hormone ... See more keywords
KNDy neurones and GnRH/LH pulse generation: Current understanding and future aspects.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuroendocrinology"
DOI: 10.1111/jne.13285
Abstract: Uncovering the central mechanism underlying mammalian reproduction is warranted to develop new therapeutic approaches for reproductive disorders in humans and domestic animals. The present study focused on the role of arcuate kisspeptin neurones (also known… read more here.
Keywords: generation current; current understanding; kndy neurones; gnrh pulse ... See more keywords
12218 Gnrh Pulse Frequency And Irregularity Play A Role In Depression
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.1223
Abstract: Abstract Disclosure: J. Choi: None. M. Kim: None. Gonadotropin-releasing hormone (GnRH) has a role in hypothalamic control of depression, but the underlying patterns and relationship with downstream reproductive hormones are still unclear. Here we report… read more here.
Keywords: pulse frequency; gnrh pulse; depression; gnrh pulses ... See more keywords
Regulation of GnRH pulsatility in ewes.
Sign Up to like & getrecommendations! Published in 2018 at "Reproduction"
DOI: 10.1530/rep-18-0127
Abstract: Early work in ewes provided a wealth of information on the physiological regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by internal and external inputs. Identification of the neural systems involved, however, was limited by the… read more here.
Keywords: gnrh; kndy neurons; gnrh pulse; kisspeptin ... See more keywords
GnRH pulse generator activity in mouse models of polycystic ovary syndrome
Sign Up to like & getrecommendations! Published in 2024 at "eLife"
DOI: 10.7554/elife.97179
Abstract: One in ten women in their reproductive age suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility. As such, it is suspected that the arcuate… read more here.
Keywords: pulse generator; gnrh pulse; gnrh; mouse ... See more keywords