GOF Mutant p53 in Cancers: A Therapeutic Challenge
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DOI: 10.3390/cancers14205091
Abstract: Simple Summary In normal cells, p53 is a protein which regulates the cell cycle progression to ensure normal cell division, growth, and development. However, in cancer, changes in the p53 DNA sequence, called genetic mutation,… read more here.
Keywords: cancers therapeutic; mutant p53; p53 cancers; p53 ... See more keywords
Gain of Function (GOF) Mutant p53 in Cancer—Current Therapeutic Approaches
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113287
Abstract: Continuous development of personalized treatments is undoubtedly beneficial for oncogenic patients’ comfort and survival rate. Mutant TP53 is associated with a worse prognosis due to the occurrence of metastases, increased chemoresistance, and tumor growth. Currently,… read more here.
Keywords: function gof; gain function; mutant p53; p53 ... See more keywords