Evaluation of the antiparasitic activities of imidazol‐2‐ylidene–gold(I) complexes
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900363
Abstract: A series of cationic gold(I)–carbene complexes with various 4,5‐diarylimidazolylidene ligands were either newly prepared or repurposed for testing against protozoal Leishmania major, Toxoplasma gondii, and Trypanosoma brucei parasites. The syntheses of the new complexes 1b… read more here.
Keywords: major amastigotes; antiparasitic activities; gold; showed highest ... See more keywords
Cationic and Neutral N‐Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI‐60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800181
Abstract: A structurally diverse library of 14 gold(I) cationic bis(NHC) and neutral mono(NHC) complexes (NHC: N‐heterocyclic carbene) was synthesized and characterized in this work. Four of them were new cationic gold(I) complexes containing functionalized NHCs, and… read more here.
Keywords: thioredoxin reductase; gold; cytotoxicity; gold complexes ... See more keywords
Anti-tumoural [NHC(thiolato)]Au(I) complexes derived from HIF-1α inhibitor AC1-004 target the mitochondrial redox system and show antiangiogenic effects in vivo.
Sign Up to like & getrecommendations! Published in 2023 at "ChemPlusChem"
DOI: 10.1002/cplu.202300167
Abstract: AC1-004 is a potent inhibitor of the hypoxia-inducible factor alpha (HIF-1α) pathway, essential for tumour growth, angiogenesis and metastasis. We modelled a series of gold(I) complexes on AC1-004, retaining its 5-carboalkoxybenzimidazole as an NHC ligand… read more here.
Keywords: antiangiogenic effects; gold complexes; inhibitor; ac1 004 ... See more keywords
Lipophilic gold(I) complexes with 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione moieties: synthesis and their cytotoxic and antimicrobial activities
Sign Up to like & getrecommendations! Published in 2017 at "BioMetals"
DOI: 10.1007/s10534-017-0046-6
Abstract: Novel lipophilic gold(I) complexes containing 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione derivatives were synthesized and characterized by IR, high resolution mass spectrometry, and 1H, 13C 31P NMR. The cytotoxicity of the compounds was evaluated considering cisplatin and/or auranofin… read more here.
Keywords: oxadiazol thione; lipophilic gold; gold; thione thiazolidine ... See more keywords
Advances in diphosphine ligand-containing gold complexes as anticancer agents
Sign Up to like & getrecommendations! Published in 2019 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2019.02.027
Abstract: Abstract The last decade has witnessed tremendous advances in the design of anticancer gold complexes containing tertiary phosphines, a class of ligands that have significantly contributed to the development of metal complexes owing to their… read more here.
Keywords: advances diphosphine; ligand; gold complexes; anticancer gold ... See more keywords
Neutral dinuclear gold(I) complexes with N-phosphanyl, N-heterocyclic carbenes (NHCPs)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2016.09.030
Abstract: Abstract Neutral dinuclear gold(I) complexes having general formula [Au 2 Cl 2 (NHCP)] (NHCP = N -phosphanyl N -heterocyclic carbene) have been synthesized by two different synthetic procedures: i) transmetalation of the NHCP ligand from the… read more here.
Keywords: neutral dinuclear; phosphanyl heterocyclic; gold; dinuclear gold ... See more keywords
Revisiting the mechanism of acetylenic amine N-Oxide rearrangement catalysed by Gold(I) complexes from a DFT perspective
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2019.03.011
Abstract: Abstract In this study, we used density functional theory (DFT) to reinvestigate the mechanism proposed by Houk and Zhang et al. (J. Am. Chem. Soc. 2012, 134, 1078) for piperidinone formation through rearrangement of an acetylenic amine… read more here.
Keywords: amine oxide; acetylenic amine; gold complexes; rearrangement ... See more keywords
Aggregation versus Biological Activity in Gold(I) Complexes. An Unexplored Concept.
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.1c02359
Abstract: The aggregation process of a series of mono- and dinuclear gold(I) complexes containing a 4-ethynylaniline ligand and a phosphane at the second coordination position (PR3-Au-C≡CC6H4-NH2, complexes 1-5, and (diphos)(Au-C≡CC6H4-NH2)2, complexes 6-8), whose biological activity was… read more here.
Keywords: biological activity; aggregation; gold complexes; aggregation versus ... See more keywords
Reactivity of Diamines in Acyclic Diamino Carbene Gold Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.2c00509
Abstract: Acyclic diamino carbenes (ADCs) are interesting alternatives to their more widely studied N-heterocyclic carbene counterparts, particularly due to their greater synthetic accessibility and properties such as increased sigma donation and structural flexibility. ADC gold complexes… read more here.
Keywords: acyclic diamino; gold complexes; adc gold; gold ... See more keywords
Histidine Targeting Heterobimetallic Ruthenium(II)-Gold(I) Complexes.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.8b03069
Abstract: Inspired by the preferential, allosteric binding of RAPTA-T and auranofin to the nucleosome core particle , we describe the design and synthesis of a series of heterobimetallic ruthenium(II)-gold(I) complexes with varying spacer lengths ranging from… read more here.
Keywords: heterobimetallic ruthenium; ruthenium gold; gold complexes; histidine targeting ... See more keywords
Luminescent Di- and Tetranuclear Gold Complexes of Bis(diphenylphosphinyl)-Functionalized Dipyrido-Annulated N-Heterocyclic Carbene.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.9b00514
Abstract: Phosphine-functionalized N-heterocyclic carbene (NHC) ligands are known to complex group 11 metal centers to form multinuclear complexes with photoluminescence properties. This study reports a structurally rigid ortho-substituted dipyrido-annulated NHC with T-shape coordination geometry and its… read more here.
Keywords: metal; dipyrido annulated; tetranuclear gold; gold complexes ... See more keywords