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Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12906
Abstract: In fundamental research and drug discovery, there is still a need for effective and straightforward chemical approaches for generating cyclic peptides. The divergent synthesis of cyclic peptides remains a challenge, in particular when cyclization is…
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Keywords:
cyclic peptides;
gold mediated;
rapid cyclization;
imine ... See more keywords
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Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2019.1696789
Abstract: Abstract C(sp3)-H alkylation at α-position of methyl-keto group on D-ring of Steroidal diglycoside (SG) with (i) C=N of Schiff base imines to form amine derivatives and (ii) C=C of acrylate Michael acceptors to form Markovnikov…
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Keywords:
steroidal diglycoside;
sp3 functionalization;
mediated sp3;
cancer ... See more keywords