The Golgi complex: 120 years and it doesn't show
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13577
Abstract: Hundred and twenty years after its discovery, the Golgi complex still attracts the interest of cell biologists, and many yet open questions address both ‘old’ and ‘new’ aspects of its function. Over this long period,… read more here.
Keywords: golgi complex; era; golgi; special issue ... See more keywords
Disulfide bond formation and redox regulation in the Golgi apparatus
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14510
Abstract: Formation of disulfide bonds in secreted and cell‐surface proteins involves numerous enzymes and chaperones abundant in the endoplasmic reticulum (ER), the first and main site for disulfide bonding in the secretory pathway. Although the Golgi… read more here.
Keywords: disulfide; formation; golgi apparatus; golgi ... See more keywords
Changes in human Golgi apparatus reflect new left ventricular dimensions and function in dilated cardiomyopathy patients
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.671
Abstract: Dilated cardiomyopathy (DCM) is a progressive disease characterized by ventricular chamber enlargement and contractile dysfunction. Natriuretic peptides (NPs) are state of the art for diagnosis and prognosis.1 Their secretion appears to depend on cardiac location,2… read more here.
Keywords: dimensions function; human golgi; golgi; golgi apparatus ... See more keywords
Disease‐causing missense mutations within the N‐terminal transmembrane domain of GlcNAc‐1‐phosphotransferase impair endoplasmic reticulum translocation or Golgi retention
Sign Up to like & getrecommendations! Published in 2020 at "Human Mutation"
DOI: 10.1002/humu.24019
Abstract: Transport of newly synthesized lysosomal enzymes to the lysosome requires tagging of these enzymes with the mannose 6‐phosphate moiety by UDP‐GlcNAc:lysosomal enzyme N‐acetylglucosamine‐1‐phosphotransferase (GlcNAc‐1‐phosphotransferase), encoded by two genes, GNPTAB and GNPTG. GNPTAB encodes the α… read more here.
Keywords: phosphotransferase; mutations within; terminal transmembrane; golgi ... See more keywords
Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_65
Abstract: The conserved oligomeric Golgi (COG) complex is an evolutionary conserved multi-subunit vesicle tethering complex essential for the majority of Golgi apparatus functions: protein and lipid glycosylation and protein sorting. COG is present in neuronal cells,… read more here.
Keywords: conserved oligomeric; vesicular trafficking; golgi; neuronal vesicular ... See more keywords
Amyotrophic lateral sclerosis-linked UBQLN2 mutants inhibit endoplasmic reticulum to Golgi transport, leading to Golgi fragmentation and ER stress
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03394-w
Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative diseases that are related genetically and pathologically. Mutations in the UBQLN2 gene, encoding the ubiquitin-like protein ubiquilin2, are associated with familial ALS/FTD, but the… read more here.
Keywords: endoplasmic reticulum; golgi; amyotrophic lateral; reticulum golgi ... See more keywords
isGPT: An optimized model to identify sub-Golgi protein types using SVM and Random Forest based feature selection
Sign Up to like & getrecommendations! Published in 2018 at "Artificial intelligence in medicine"
DOI: 10.1016/j.artmed.2017.11.003
Abstract: The Golgi Apparatus (GA) is a key organelle for protein synthesis within the eukaryotic cell. The main task of GA is to modify and sort proteins for transport throughout the cell. Proteins permeate through the… read more here.
Keywords: golgi protein; golgi; sub golgi; model ... See more keywords
Regulation of glucosylceramide synthesis by Golgi-localized phosphoinositide.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.039
Abstract: Phosphoinositides mediate a large number of signaling processes in mammalian cells. Here, we report that phophatidylinositol-4-phosphate (PtdIns(4)P) downregulates the cellular glucosylceramide (GlcCer) level by inhibiting the interaction between GlcCer synthase (UGCG) and UDP-glucose in the… read more here.
Keywords: ugcg activity; synthesis; golgi; activity ... See more keywords
ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109707
Abstract: Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before transport to the Golgi apparatus. Decades of research have provided many details of the molecular events underlying ER-Golgi exchanges. Essential questions, however, remain… read more here.
Keywords: microscopy; golgi; sites drosophila; exit sites ... See more keywords
A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.02.025
Abstract: Phosphatidylinositol (PtdIns) transfer proteins (PITPs) stimulate PtdIns-4-P synthesis and signaling in eukaryotic cells, but to what biological outcomes such signaling circuits are coupled remains unclear. Herein, we show that two highly related StART-like PITPs, PITPNA… read more here.
Keywords: pathway controls; golgi; lipid signaling; signaling pathway ... See more keywords
The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network
Sign Up to like & getrecommendations! Published in 2017 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2017.06.024
Abstract: Genome-Wide Association Studies (GWAS) and subsequent fine-mapping studies (> 50) have implicated single nucleotide polymorphisms (SNPs) located at the CCDC170/C6ORF97-ESR1 locus (6q25.1) as being associated with the risk of breast cancer. Surprisingly, our analysis using… read more here.
Keywords: protein; golgi; ccdc170; breast cancer ... See more keywords