Wolfram syndrome: clinical and genetic profiling of a cohort from a tertiary care centre with characterization of the primary gonadal failure
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DOI: 10.1007/s12020-020-02320-6
Abstract: Background Wolfram syndrome (WFS) is a rare, monogenic neurodegenerative syndrome characterised by insulin requiring non-autoimmune diabetes mellitus (DM) and optic atrophy which are usually the earliest and commonest manifestations. However, there are other features which… read more here.
Keywords: primary gonadal; gonadal failure; wolfram syndrome; care centre ... See more keywords
Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for Prevention.
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DOI: 10.1159/000515460
Abstract: Modern advances in oncological treatments determined a significant improvement in survival rates for several malignancies. Nevertheless, survivorship and quality of life of cancer survivors may be negatively impaired by metabolic and endocrine side effects related… read more here.
Keywords: gonadal failure; cancer survivors; infertility cancer; cancer ... See more keywords
Gonadal Failure Is Common in Long-Term Survivors of Childhood High-Risk Neuroblastoma Treated With High-Dose Chemotherapy and Autologous Stem Cell Rescue
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DOI: 10.3389/fendo.2019.00555
Abstract: Background: Neuroblastoma is the most common extra-cranial solid tumor in children. Intensive therapy including autologous stem-cell transplantation (HSCT) has improved the poor prognosis of high-risk neuroblastoma (HR-NBL) but may impair gonadal function. Objectives: To investigate… read more here.
Keywords: term; long term; gonadal failure; term survivors ... See more keywords