Antimicrobial‐resistant Neisseria gonorrhoeae can be targeted using inhibitors against evolutionary conservedl‐asparaginase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30271
Abstract: The emergence of multiple drug‐resistant “super gonorrhoea” complicates the management and treatment of Neisseria gonorrhoeae infections due to the progressive accumulation of mutations in the biological targets of frontline antimicrobials. Continuous evaluation and reporting of… read more here.
Keywords: neisseria gonorrhoeae; asparaginase; antimicrobial resistant; drug ... See more keywords
A Cost Analysis of Gyrase A Testing and Targeted Ciprofloxacin Therapy Versus Recommended 2-Drug Therapy for Neisseria gonorrhoeae Infection
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DOI: 10.1097/olq.0000000000000698
Abstract: BackgroundNovel approaches to combating drug-resistant Neisseria gonorrhoeae infections are urgently needed. Targeted therapy with ciprofloxacin has been made possible by a rapid assay for genotyping the gyrase A (gyrA) gene; a nonmutated gene reliably predicts… read more here.
Keywords: drug therapy; gonorrhoeae; ciprofloxacin; therapy ... See more keywords
In vitro Susceptibility to β-Lactam Antibiotics and Viability of Neisseria gonorrhoeae Strains Producing Plasmid-Mediated Broad- and Extended-Spectrum β-Lactamases
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DOI: 10.1101/2022.03.11.483876
Abstract: N. gonorrhoeae strains producing plasmid-mediated broad- and extended-spectrum β-lactamases (ESBLs) have been obtained in vitro and studied for their viability and susceptibility to β-lactam antibiotics. The artificial pblaTEM-1 and pblaTEM-20 plasmids were constructed by site-directed… read more here.
Keywords: plasmid; gonorrhoeae strains; pblatem; lactam antibiotics ... See more keywords
Applications of genomics to slow the spread of multidrug‐resistant Neisseria gonorrhoeae
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DOI: 10.1111/nyas.13871
Abstract: Infections with Neisseria gonorrhoeae, a sexually transmitted pathogen that causes urethritis, cervicitis, and more severe complications, are increasing. Gonorrhea is typically treated with antibiotics; however, N. gonorrhoeae has rapidly acquired resistance to many antibiotic classes,… read more here.
Keywords: neisseria gonorrhoeae; resistance; applications genomics; spread ... See more keywords
Emergence and Spread of Neisseria gonorrhoeae Strains with High-Level Resistance to Azithromycin in Taiwan from 2001 to 2018
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00773-19
Abstract: A total of 598 Neisseria gonorrhoeae isolates obtained from patients in Taiwan from 2001 to 2018 were evaluated. The MICs of ceftriaxone (CRO) and azithromycin (AZM) against the isolates were determined by the agar dilution… read more here.
Keywords: gonorrhoeae; taiwan 2001; gonorrhoeae isolates; neisseria gonorrhoeae ... See more keywords
A Multiplex Molecular Assay for Detection of Six penA Codons To Predict Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae
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DOI: 10.1128/aac.01709-21
Abstract: The emerging cephalosporin-resistant Neisseria gonorrhoeae poses an urgent threat to the continued efficacy of the last-line monotherapy for gonorrhea. Consequently, high-throughput, accurate, and reasonable molecular assays are urgently needed for strengthening antimicrobial-resistance surveillance in N.… read more here.
Keywords: gonorrhoeae; neisseria gonorrhoeae; resistance; cephalosporin resistant ... See more keywords
Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart
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DOI: 10.1128/iai.00658-18
Abstract: Neisseria gonorrhoeae, the causative agent of gonorrhea, has evolved several mechanisms to subvert complement, including binding of the complement inhibitor factor H (FH). We previously reported FH binding to N. gonorrhoeae independently of lipooligosaccharide (LOS)… read more here.
Keywords: neisserial surface; nspa; factor; gonorrhoeae ... See more keywords
Variable Expression of Opa Proteins by Neisseria gonorrhoeae Influences Bacterial Association and Phagocytic Killing by Human Neutrophils
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00035-22
Abstract: Neisseria gonorrhoeae, the cause of gonorrhea, is an urgent-threat pathogen due to increasing numbers of infections and increased antibiotic resistance. Many surface components of N. gonorrhoeae are phase variable, including the Opa protein family of… read more here.
Keywords: human neutrophils; neisseria gonorrhoeae; expression; gonorrhoeae ... See more keywords
Multiplex Real-Time PCR Assay for Simultaneous Identification of Neisseria gonorrhoeae and Its Ciprofloxacin Susceptibility Status
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DOI: 10.1128/jcm.00855-17
Abstract: ABSTRACT A real-time PCR (RT-PCR) assay was designed for the simultaneous identification of Neisseria gonorrhoeae and its ciprofloxacin susceptibility status. A SYBR green-based multiplex RT-PCR format was used; it comprised two different forward primers and… read more here.
Keywords: ciprofloxacin susceptibility; gonorrhoeae ciprofloxacin; gonorrhoeae; susceptibility status ... See more keywords
Potent In Vitro and Ex Vivo Anti-Gonococcal Activity of the RpoB Inhibitor Corallopyronin A
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DOI: 10.1128/msphere.00362-22
Abstract: The high global incidence of gonorrhea, the lack of a protective vaccine, and the emergence of N. gonorrhoeae strains expressing resistance to currently used antibiotics demand that new treatment options be developed. Accordingly, we investigated… read more here.
Keywords: vitro vivo; resistance; anti gonococcal; emergence ... See more keywords
Loop-Mediated Isothermal Amplification Assay for Identifying Neisseria gonorrhoeae Nonmosaic penA-Targeting Strains Potentially Eradicable by Cefixime
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DOI: 10.1128/spectrum.02335-22
Abstract: Neisseria gonorrhoeae is among the hot topics of “resistance guided therapy,” one of the top 5 urgent antimicrobial threats according to the Centers for Disease Control and Prevention (CDC). There is a need either to… read more here.
Keywords: neisseria gonorrhoeae; pena; gonorrhoeae; resistance ... See more keywords