Tackling Challenging Data Integrity Topics in 2020: Update on Good Clinical Practice Perspectives from US FDA and MHRA UK.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2386
Abstract: With the globalization of clinical trials, regulators have increased collaboration to evaluate the adequacy of clinical trial conduct and to optimize regulatory oversight. The 2020 joint Good Clinical Practice (GCP) symposium of the US Food… read more here.
Keywords: data integrity; clinical trial; clinical practice; good clinical ... See more keywords
Identification Of Strn-Ntrk2 Rearrangement In A High Grade Sarcoma, With Good Clinical Response To Firstline Larotrectinib Therapy
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa161.173
Abstract: Gene fusions involving tropomyosin receptor kinase genes, NTRK (NTRK1-3), are important in tumorigenesis. Larotrectinib, a selective NTRK inhibitor, is recently approved to treat NTRK fusion positive solid tumors. We herein report a case of soft… read more here.
Keywords: sarcoma; clinical response; good clinical; larotrectinib ... See more keywords
Laterality of previous stoke affects endovascular thrombectomy outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/neurintsurg-2021-018011
Abstract: Background Investigations into the effect of previous stroke on thrombectomy outcomes have yielded conflicting results, and are limited by small sample sizes. We present the results of a large single center retrospective study aimed at… read more here.
Keywords: patients chronic; thrombectomy; laterality previous; endovascular thrombectomy ... See more keywords