Cobalt Ferrite-Gossypol Coordination Nanoagents with High Photothermal Conversion Efficiency Sensitizing Chemotherapy against Bcl-2 to Induce Tumor Apoptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202300104
Abstract: Gossypol is a chemotherapeutic drug that can inhibit the anti-apoptotic protein Bcl-2, but the existing gossypol-related nanocarriers cannot well solve the problem of chemotherapy resistance. Based on the observation that gossypol becomes black upon Fe3+… read more here.
Keywords: cobalt ferrite; coordination; tumor; chemotherapy ... See more keywords
Gossypol detoxification in the rumen and Helicoverpa armigera larvae: A review
Sign Up to like & getrecommendations! Published in 2021 at "Animal Nutrition"
DOI: 10.1016/j.aninu.2021.02.007
Abstract: Gossypol, a phenolic compound found in the cotton plant, is widely distributed in cottonseed by-products. Although ruminant animals are believed to be more tolerant of gossypol toxicity than monogastric animals due to rumen microbial fermentation,… read more here.
Keywords: gossypol detoxification; detoxification; armigera; detoxification rumen ... See more keywords
Spectroscopic study of stepwise gossypol sulfonylation with tosyl chloride in the presence of 4-methoxypyridine N-oxide and triethylamine
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131155
Abstract: Abstract Sulfonylation of gossypol with stepwise increase of tosyl chloride content in the presence of 4-methoxypyridine N-oxide and triethylamine was carried out. The sequence of gossypol's hydroxyl groups tosylation was studied using HPLC, FT-IR and… read more here.
Keywords: methoxypyridine oxide; spectroscopy; triethylamine; tosyl chloride ... See more keywords
Yeast Chemogenomic Profiling Reveals Iron Chelation To Be the Principle Cell Inhibitory Mode of Action of Gossypol.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00692
Abstract: Gossypol is an inhibitor of eukaryotic cells with an undetermined mode of action. Here we show that the chemogenomic profile of gossypol is strikingly similar to that of the iron chelators deferasirox and desferricoprogen. Iron… read more here.
Keywords: chelation; principle; mode action; gossypol ... See more keywords
A gossypol biosynthetic intermediate disturbs plant defence response
Sign Up to like & getrecommendations! Published in 2019 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2018.0319
Abstract: Plant secondary metabolites and their biosynthesis have attracted great interest, but investigations of the activities of hidden intermediates remain rare. Gossypol and related sesquiterpenes are the major phytoalexins in cotton. Among the six biosynthetic intermediates… read more here.
Keywords: gossypol; defence response; plant; c234 ... See more keywords
Gossypol Promotes Bone Formation in Ovariectomy-Induced Osteoporosis through Regulating Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/3635485
Abstract: Osteoporosis is among the most common forms of age-related diseases, especially for females, which has been a grave public health problem. Drug therapies have shown promising outcomes to promote bone formation and bone density. This… read more here.
Keywords: bone formation; ovariectomy induced; induced osteoporosis; gossypol ... See more keywords
Gestational and lactational exposure to gossypol alters the testis transcriptome
Sign Up to like & getrecommendations! Published in 2020 at "BMC Genomics"
DOI: 10.1186/s12864-020-6487-2
Abstract: Background Reproductive capacity can be altered by challenges experienced during critical periods of development, including fetal development and early neonatal life. Gossypol is a polyphenolic compound, commonly found in cotton seeds, that impairs male reproduction.… read more here.
Keywords: gestational lactational; gossypol alters; testis transcriptome; exposure gossypol ... See more keywords
Cotton roots are the major source of gossypol biosynthesis and accumulation
Sign Up to like & getrecommendations! Published in 2020 at "BMC Plant Biology"
DOI: 10.1186/s12870-020-2294-9
Abstract: Background Gossypol is a specific secondary metabolite in Gossypium species. It not only plays a critical role in development and self-protection of cotton plants, but also can be used as important anti-cancer and male contraceptive… read more here.
Keywords: source gossypol; cotton; gossypol biosynthesis; gossypol ... See more keywords
The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis
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DOI: 10.1667/rr14620.1
Abstract: Exposure of the lung to ionizing radiation that occurs in radiotherapy, as well as after accidental or intentional mass casualty incident can result in pulmonary fibrosis, which has few treatment options. Pulmonary fibrosis is characterized… read more here.
Keywords: fibrosis; radiation induced; induced pulmonary; pulmonary fibrosis ... See more keywords
Cyclic RGD-Decorated Liposomal Gossypol AT-101 Targeting for Enhanced Antitumor Effect
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s341824
Abstract: Introduction (-)-Gossypol (AT-101), the (-)-enantiomer of the natural compound gossypol, has shown significant inhibitory effects on various types of cancers such as osteosarcoma, myeloma, glioma, lung cancer, and prostate cancer. However, the clinical application of… read more here.
Keywords: effect; crgd; antitumor effect; gos crgd ... See more keywords
Presence of free gossypol in whole cottonseed
Sign Up to like & getrecommendations! Published in 2017 at "EFSA Journal"
DOI: 10.2903/j.efsa.2017.4850
Abstract: Abstract The European Commission asked EFSA to assess information provided by the Spanish Ministry of Agriculture, Food and Environment, on the toxicity of free gossypol in relation to the use of whole cotton seed in… read more here.
Keywords: presence free; pima varieties; gossypol; feed ... See more keywords