Crystal arthritis: Stepping up febuxostat to treat gout flares
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2017.193
Abstract: A stepwise dose increase of febuxostat was comparable to prophylactic low-dose colchicine for reducing flares in an open-label, randomized study of 241 patients with gout. Flares occurred in 20.8% of patients taking stepped-up (10 mg… read more here.
Keywords: stepping febuxostat; patients taking; daily febuxostat; gout flares ... See more keywords
Serum uric acid levels and the risk of flares among gout patients in a US managed care setting
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2016.1239193
Abstract: Abstract Objective: Serum uric acid (sUA) levels are causally associated with the risk of gout flares. Our aim was to assess the magnitude of the association and time to first flare among patients in a… read more here.
Keywords: gout flares; sua levels; sua sua; sua ... See more keywords
Prescribing patterns and healthcare costs of gout
Sign Up to like & getrecommendations! Published in 2019 at "Current Medical Research and Opinion"
DOI: 10.1080/03007995.2018.1552577
Abstract: Abstract Objective/methods: The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and their number of gout flares. Results: Out of 21,376 gout patients, a total of 3561 (16.7%) had frequent gout… read more here.
Keywords: gout flares; healthcare costs; gout; frequent gout ... See more keywords
Ultrasonography in the prediction of gout flares: a 12-month prospective observational study.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac367
Abstract: OBJECTIVES To evaluate whether ultrasound (US) findings indicating monosodium urate (MSU) deposits and US-detected inflammation [i.e. power Doppler (PD) signal] predict gout flares over 12 months. METHODS Gout patients on urate-lowering therapy for at least the… read more here.
Keywords: rheumatology; msu deposits; gout; msu ... See more keywords
Anakinra for the treatment of acute gout flares: a randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial.
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology"
DOI: 10.1093/rheumatology/key402
Abstract: Objectives To evaluate the efficacy and safety of anakinra in treating acute gout flares in a randomized, double-blind, placebo-controlled, active comparator, non-inferiority (NI) trial. Methods Patients with a crystal-proven acute gout flare were randomized (1:… read more here.
Keywords: trial; treatment; acute gout; gout flares ... See more keywords
Zhengqing fengtongning sustained-release tablets prevents gout flares in the process of ULT
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029199
Abstract: Abstract Introduction: When initiating urate-lowering therapy, using anti-inflammatory prophylaxis therapy for at least 3 to 6 months is strongly recommended. Previous studies have found that zhengqing fengtongning sustained-release tablets (sinomenine) can improve inflammation in the acute… read more here.
Keywords: gout; fengtongning sustained; therapy; zhengqing fengtongning ... See more keywords
Risk of gout flares after vaccination: a prospective case cross-over study
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-215724
Abstract: Objectives The recombinant zoster vaccine (RZV) containing a strong non-aluminium adjuvant is associated with increased risk of gout flares, presumably via NLRP3 inflammasome activation. We tested the possibility that other vaccines may also be associated… read more here.
Keywords: gout flares; study; case; gout ... See more keywords
Clarification regarding the statement of the association between the recombinant zoster vaccine (RZV) and gout flares.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the rheumatic diseases"
DOI: 10.1136/annrheumdis-2019-216639
Abstract: We have read with great interest the article addressing the risk of gout flares after vaccination in a case crossover study by Yokose et al .1 The authors suggest that vaccines may be associated with… read more here.
Keywords: zoster vaccine; gout flares; recombinant zoster; gout ... See more keywords
SAT0402 SEL-212 PHASE 2 CLINICAL STUDY IN SYMPTOMATIC GOUT PATIENTS: IMMTOR TOLEROGENIC NANOPARTICLES COMBINED WITH PEGADRICASE MITIGATES IMMUNOGENICITY AND ENABLES SUSTAINED REDUCTION OF SERUM URIC ACID LEVELS, LOW RATE OF GOUT FLARES AND MONTHLY DOSING
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.7769
Abstract: Background: Pegylated uricases are promising therapies for the treatment of severe chronic gout, but are limited by their immunogenicity. We have previously shown that ImmTOR tolerogenic nanoparticles (formerly known as SVP-Rapamycin) encapsulating rapamycin co-administered with… read more here.
Keywords: biosciences inc; selecta biosciences; gout; gout flares ... See more keywords
Colchicine prophylaxis is associated with fewer gout flares after COVID-19 vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2022-222199
Abstract: Objectives COVID-19 vaccination often triggers a constellation of transitory inflammatory symptoms. Gout is associated with several comorbidities linked to poor outcomes in COVID-19, and gout flares can be triggered by some vaccinations. We analysed the… read more here.
Keywords: gout flare; vaccination; gout; colchicine prophylaxis ... See more keywords