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   Articles with "gouty arthritis" as a keyword



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Calycosin represses AIM2 inflammasome‐mediated inflammation and pyroptosis to attenuate monosodium urate‐induced gouty arthritis through NF‐κB and p62‐Keap1 pathways

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recommendations! Published in 2022 at "Drug Development Research"

DOI: 10.1002/ddr.21985

Abstract: Gouty arthritis is an inflammatory disease induced by monosodium urate (MSU), and is closely related to the activation of inflammasomes. Calycosin plays an anti‐inflammatory role in arthritis. This study explored the mechanism of Calycosin in… read more here.

Keywords: calycosin; pyroptosis; gouty arthritis; msu induced ... See more keywords
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Ancient herbal component may be a novel therapeutic for gouty arthritis

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recommendations! Published in 2019 at "Journal of Leukocyte Biology"

DOI: 10.1002/jlb.3ce1018-384r

Abstract: Rhodiola species are flowering perennial plants in Crassulaceae family that have been used in folk medicine in Asia and Europe for thousands of years. In traditional Chinese medicine, Rhodiola species was initially documented in Sheng… read more here.

Keywords: gouty; medicine; sal; rhodiola species ... See more keywords
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Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study

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recommendations! Published in 2020 at "Journal of Natural Medicines"

DOI: 10.1007/s11418-020-01440-7

Abstract: Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess anti-inflammatory property. Nevertheless, the role of dioscin in GA and the underlying mechanism have not… read more here.

Keywords: dioscin; gouty arthritis; effect; activation ... See more keywords
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In Vivo Effects of Orally Administered Different Concentrations of Silver Oxide Nanoparticles in Hyperuricemic Mice.

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recommendations! Published in 2021 at "Biological trace element research"

DOI: 10.1007/s12011-021-02960-3

Abstract: Silver oxide nanoparticles (AgO-NPs) antioxidant, anti-cancer, anti-microbial, and tissue repair properties. Gouty arthritis is the inflammation of tissues and joints caused by the deposition of monosodium urate crystals. In this experiment, we investigated the anti-hyperuricemic… read more here.

Keywords: gouty arthritis; different concentrations; silver oxide; ago nps ... See more keywords
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Serum levels of IL-17 are elevated in patients with acute gouty arthritis.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.02.166

Abstract: Acute gouty arthritis (AGA) is one of the most common forms of auto-inflammatory arthritis. IL-17 is a key proinflammatory cytokine which has been implicated in several autoimmune diseases. However, to date little is known about… read more here.

Keywords: gouty arthritis; levels elevated; serum levels; arthritis ... See more keywords
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Modified Simiaowan Prevents Articular Cartilage Injury in Experimental Gouty Arthritis by Negative Regulation of STAT3 Pathway.

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recommendations! Published in 2021 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2021.113825

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Modified Simiaowan (MSW) is a traditional Chinese medicine formula that composes of six herbs. It has been widely used in the treatment of gouty arthritis. AIM OF THE STUDY This study was designed… read more here.

Keywords: gouty arthritis; arthritis; modified simiaowan; stat3 pathway ... See more keywords
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Silencing of gasdermin D by siRNA-loaded PEI-Chol lipopolymers potently relieves acute gouty arthritis through inhibiting pyroptosis.

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recommendations! Published in 2020 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.0c00229

Abstract: Gasdermin D (GSDMD) serves as a causal role in NOD-like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis eruption, which has been regarded as a potential therapeutic target for pyroptosis-related diseases including acute gouty arthritis. In the… read more here.

Keywords: gouty arthritis; pei chol; pyroptosis; acute gouty ... See more keywords
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Biomineralized Nanoscavenger Abrogates Proinflammatory Macrophage Polarization and Induces Neutrophil Clearance through Reverse Migration during Gouty Arthritis.

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recommendations! Published in 2023 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.2c19684

Abstract: The deposition of monosodium urate (MSU) crystals induces the overexpression of reactive oxygen species (ROS) and proinflammatory cytokines in residential macrophages, further promoting the infiltration of inflammatory leukocytes in the joints of gouty arthritis. Herein,… read more here.

Keywords: reverse migration; arthritis; gouty arthritis; msu induced ... See more keywords
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MicroRNA-142-3p facilitates inflammatory response by targeting ZEB2 and activating NF-κB signaling in gouty arthritis

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recommendations! Published in 2022 at "Cell Cycle"

DOI: 10.1080/15384101.2022.2031678

Abstract: ABSTRACT Gouty arthritis (GA) is caused by monosodium urate (MSU) crystal accumulation in the joints. MSU-mediated inflammation is an important inducing factor in gouty arthritis (GA). Recent studies have demonstrated that microRNAs can influence GA… read more here.

Keywords: mirna 142; inflammatory response; zeb2; gouty arthritis ... See more keywords
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Cynarin suppresses gouty arthritis induced by monosodium urate crystals

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2072055

Abstract: ABSTRACT The study is aimed to determine the effects of cynarin (Cyn) on mice with gouty arthritis (GA) induced by monosodium urate (MSU). We measured swelling in the hind paws of mice in vivo using… read more here.

Keywords: hind paws; monosodium urate; induced monosodium; gouty arthritis ... See more keywords
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Treatment of atypical gouty arthritis of the hip using total hip arthroplasty

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recommendations! Published in 2020 at "Medicine"

DOI: 10.1097/md.0000000000023027

Abstract: Abstract Rationale: Gout and gouty arthritis typically involve peripheral and monoarticular joints, especially the first metatarsophalangeal joint and knees. Hip involvement in patients with gout is rare, and its diagnosis is very difficult, especially in… read more here.

Keywords: hip arthroplasty; total hip; gout; gouty arthritis ... See more keywords