Autoreactivity and broad neutralization of antibodies against HIV-1 are governed by distinct mutations: Implications for vaccine design strategies
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DOI: 10.3389/fimmu.2022.977630
Abstract: Many of the best HIV-1 broadly neutralizing antibodies (bnAbs) known have poly-/autoreactive features that disfavor normal B cell development and maturation, posing a major hurdle in developing an effective HIV-1 vaccine. Key to resolving this… read more here.
Keywords: autoreactivity; neutralization; broad neutralization; governed distinct ... See more keywords