HIV-1 gp120 Upregulates Brain-Derived Neurotrophic Factor (BDNF) Expression in BV2 Cells via the Wnt/β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0931-z
Abstract: HIV-1 gp120 plays a critical role in the pathogenesis of HIV-associated pain, but the underlying molecular mechanisms are incompletely understood. This study aims to determine the effect and possible mechanism of HIV-1 gp120 on BDNF… read more here.
Keywords: catenin; gp120; bv2 cells; bdnf expression ... See more keywords
Schwann cell-derived CXCL1 contributes to human immunodeficiency virus type 1 gp120-induced neuropathic pain by modulating macrophage infiltration in mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.03.027
Abstract: The neuroinflammatory responses to human immunodeficiency virus type 1 (HIV-1) coat proteins, such as glycoprotein 120 (gp120), are considered to be responsible for the HIV-associated distal sensory neuropathy. Accumulating evidences suggest that T-cell line tropic… read more here.
Keywords: schwann; infiltration; gp120; macrophage infiltration ... See more keywords
A Degraded Fragment of HIV-1 Gp120 in Rat Hepatocytes Forms Fibrils and Enhances HIV-1 Infection.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2017.08.005
Abstract: Identification of the host or viral factors that enhance HIV infection is critical for preventing sexual transmission of HIV. Amyloid fibrils derived from human semen, including semen-derived enhancer of virus infection and semenogelins, enhance HIV-1… read more here.
Keywords: hiv infection; rat hepatocytes; infection; gp120 ... See more keywords
Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.04.054
Abstract: Highlights • VRC01 epitope focused structure-based immunogen design.• Gp120 outer-domain core was further stabilized by 375 tryptophan substitution.• Epitope specific antibodies were predominately induced through guinea pig immunizations. read more here.
Keywords: gp120; domain core; outer domain; immunogen design ... See more keywords
Characterization of twin-cysteine motif in the V2-loop region of gp120 in primate lentiviruses.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.04.013
Abstract: The twin-cysteine motif (TCM) in the V2 loop region of gp120, identified in our previous report on the simian immunodeficiency virus mac239 (SIVmac239), is a conserved evolutionary element in all primate lentiviruses except for HIV-1… read more here.
Keywords: cysteine motif; region gp120; primate lentiviruses; twin cysteine ... See more keywords
Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2018.06.005
Abstract: The V3 loop of the human immunodeficiency virus type 1 (HIV-1) gp120 exterior envelope glycoprotein (Env) becomes exposed after CD4 binding and contacts the coreceptor to mediate viral entry. Prior to CD4 engagement, a hydrophobic… read more here.
Keywords: immunodeficiency viruses; primate immunodeficiency; gp120; loop ... See more keywords
HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0175-1
Abstract: Dear Editor, Human immunodeficiency virus type 1 (HIV-1) infection is mainly initiated on mucosal epithelial surfaces. Exposure to HIV-1 impairs the mucosal epithelial barrier, allowing viral transmission across the mucosal epithelium. Interaction of HIV-1 envelope… read more here.
Keywords: data fig; cell junctions; supplementary data; gp120 ... See more keywords
Mutation in the D1 domain of CD4 receptor modulates the binding affinity to HIV-1 gp120
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra06628a
Abstract: The gp120 surface subunit of HIV-1 envelope lycoprotein (Env) is the key component for the viral entry process through interaction with the CD4 binding site (CD4bs) of the primary receptor CD4. The point mutant was… read more here.
Keywords: cd4 receptor; gp120; hiv gp120; cd4 ... See more keywords
Study on molecular mechanisms of CD4 dependency and independency of HIV-1 gp120
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00433c
Abstract: Different HIV-1 strains have different antibody neutralization phenotypes (or CD4-dependencies). However, the molecular mechanisms underlying these differences remain to be elucidated. In this study, we constructed gp120 structural models from the CD4-dependent, neutralization-resistant JR-FL strain… read more here.
Keywords: hiv; study molecular; molecular mechanisms; gp120 ... See more keywords
The V2 loop of HIV gp120 delivers costimulatory signals to CD4+ T cells through Integrin α4β7 and promotes cellular activation and infection.
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2011501117
Abstract: Acute HIV infection is characterized by rapid viral seeding of immunologic inductive sites in the gut followed by the severe depletion of gut CD4+ T cells. Trafficking of α4β7-expressing lymphocytes to the gut is mediated… read more here.
Keywords: cd4 cells; hiv; infection; gp120 ... See more keywords
Self-assembling peptide nanofiber HIV vaccine elicits robust vaccine-induced antibody functions and modulates Fc glycosylation
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq0273
Abstract: To develop vaccines for certain key global pathogens such as HIV, it is crucial to elicit both neutralizing and non-neutralizing Fc-mediated effector antibody functions. Clinical evidence indicates that non-neutralizing antibody functions including antibody-dependent cellular cytotoxicity… read more here.
Keywords: antibody functions; glycosylation; gp120; self assembling ... See more keywords