Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS letters"
DOI: 10.1002/1873-3468.14292
Abstract: Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signaling receptor glycoprotein 130 (gp130). The structural details as well… read more here.
Keywords: staphylococcal enterotoxin; gp130; cytokine; human gp130 ... See more keywords
O39 Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.06.104
Abstract: Doxorubicin (Dox) could trigger a large amount of apoptotic cells in the myocardium, which leads to dilated cardiomyopathy and heart failure. S-propargyl-cysteine (SPRC), an endogenous hydrogen sulfide (H 2 S) initiator, possesses cardioprotective efficacy. However,… read more here.
Keywords: induced cardiotoxicity; propargyl cysteine; gp130 mediated; cardiotoxicity ... See more keywords
Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101341
Abstract: Objective Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines. The conversion of white into brown-like adipocytes (browning) may increase energy expenditure and revert the positive… read more here.
Keywords: wat; gene expression; gp130 cytokines; expression ... See more keywords
Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Obesity"
DOI: 10.1038/s41366-019-0444-7
Abstract: Background Repetitive physical activity is a well-established intervention to reduce obesity and to prevent weight regain. Besides increased energy expenditure, reduced caloric intake may contribute to exercise-induced weight loss in obesity. Using adipocyte-specific glycoprotein 130… read more here.
Keywords: gp130 adipo; weight reduction; induced weight; adipocyte specific ... See more keywords
FRI0113 THE BASELINE SOLUBLE GP130 IS ASSOCIATED WITH THE RESPONSE OF RHEUMATOID ARTHRITIS PATIENTS TO SARILUMAB
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.1737
Abstract: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Sarilumab (SRL), a human anti-human IL-6 receptor alpha monoclonal antibody that blocks the signaling originated by the IL-6/IL-6R complex like tocilizumab,is an effective… read more here.
Keywords: response; none declared; sgp130; gp130 ... See more keywords
IL-6 and Soluble Receptors in Overweight and Obese African American Women With and Without Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Biological Research For Nursing"
DOI: 10.1177/1099800420945787
Abstract: Interleukin 6 (IL-6) and its receptors are expressed in approximately half of breast cancer (BC) tissues, and high serum IL-6 levels are associated with poor prognosis. African American (AA) patients with BC have higher serum… read more here.
Keywords: gp130; women without; african american; breast cancer ... See more keywords
Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01532
Abstract: The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies… read more here.
Keywords: treg cells; human treg; foxp3; function ... See more keywords
CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.675250
Abstract: The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2… read more here.
Keywords: cd3 cd4; il6st expression; sle patients; gp130 ... See more keywords
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137089
Abstract: N-acetyl-p-aminophenol (APAP)-induced liver damage is associated with upregulation of Interleukin-11 (IL11), which is thought to stimulate IL6ST (gp130)-mediated STAT3 activity in hepatocytes, as a compensatory response. However, recent studies have found IL11/IL11RA/gp130 signaling to be… read more here.
Keywords: il11; liver injury; apap induced; induced liver ... See more keywords
Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200461
Abstract: IL-6 plays a fundamental role in T cell differentiation and is strictly controlled by surface expression and shedding of IL-6R. IL-6 also acts on other cells that might affect T cell maturation. To study the… read more here.
Keywords: cell; lgp130; gp130 signaling; mice ... See more keywords
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200788
Abstract: IL-6 family members contribute to host defense through the stimulation of acute-phase signaling, hematopoiesis, immune reactions, and regenerative processes. To investigate essential mechanisms that are linked toward a constitutively activated gp130 signaling, we generated and… read more here.
Keywords: cell; gp130 cells; activation gp130; gp130 ... See more keywords