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   Articles with "gp130" as a keyword



Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor.

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recommendations! Published in 2022 at "FEBS letters"

DOI: 10.1002/1873-3468.14292

Abstract: Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signaling receptor glycoprotein 130 (gp130). The structural details as well… read more here.

Keywords: staphylococcal enterotoxin; gp130; cytokine; human gp130 ... See more keywords

O39 Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity

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recommendations! Published in 2017 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2017.06.104

Abstract: Doxorubicin (Dox) could trigger a large amount of apoptotic cells in the myocardium, which leads to dilated cardiomyopathy and heart failure. S-propargyl-cysteine (SPRC), an endogenous hydrogen sulfide (H 2 S) initiator, possesses cardioprotective efficacy. However,… read more here.

Keywords: induced cardiotoxicity; propargyl cysteine; gp130 mediated; cardiotoxicity ... See more keywords
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Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling

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recommendations! Published in 2021 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2021.101341

Abstract: Objective Obesity is associated with low-grade adipose tissue inflammation and locally elevated levels of several glycoprotein 130 (gp130) cytokines. The conversion of white into brown-like adipocytes (browning) may increase energy expenditure and revert the positive… read more here.

Keywords: wat; gene expression; gp130 cytokines; expression ... See more keywords

Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction

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recommendations! Published in 2019 at "International Journal of Obesity"

DOI: 10.1038/s41366-019-0444-7

Abstract: Background Repetitive physical activity is a well-established intervention to reduce obesity and to prevent weight regain. Besides increased energy expenditure, reduced caloric intake may contribute to exercise-induced weight loss in obesity. Using adipocyte-specific glycoprotein 130… read more here.

Keywords: gp130 adipo; weight reduction; induced weight; adipocyte specific ... See more keywords

FRI0113 THE BASELINE SOLUBLE GP130 IS ASSOCIATED WITH THE RESPONSE OF RHEUMATOID ARTHRITIS PATIENTS TO SARILUMAB

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recommendations! Published in 2020 at "Annals of the Rheumatic Diseases"

DOI: 10.1136/annrheumdis-2020-eular.1737

Abstract: IL-6 contributes significantly to the chronic inflammatory process of rheumatoid arthritis (RA). Sarilumab (SRL), a human anti-human IL-6 receptor alpha monoclonal antibody that blocks the signaling originated by the IL-6/IL-6R complex like tocilizumab,is an effective… read more here.

Keywords: response; none declared; sgp130; gp130 ... See more keywords
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IL-6 and Soluble Receptors in Overweight and Obese African American Women With and Without Breast Cancer

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recommendations! Published in 2020 at "Biological Research For Nursing"

DOI: 10.1177/1099800420945787

Abstract: Interleukin 6 (IL-6) and its receptors are expressed in approximately half of breast cancer (BC) tissues, and high serum IL-6 levels are associated with poor prognosis. African American (AA) patients with BC have higher serum… read more here.

Keywords: gp130; women without; african american; breast cancer ... See more keywords

Structural Model of the Oncostatin M (OSM)-OSMRβ-gp130 Ternary Complex Reveals Pathways of Allosteric Communication in OSM Signaling.

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recommendations! Published in 2025 at "Current medicinal chemistry"

DOI: 10.2174/0109298673362742250508113436

Abstract: INTRODUCTION Human oncostatin M (OSM) is a pleiotropic cytokine that regulates inflammatory and immune responses by binding to the heterodimer receptor complex OSM receptor beta (OSMRβ) and glycoprotein 130 (gp130). The distinct signaling pathways triggered… read more here.

Keywords: osm signaling; gp130; osm osmr; osmr gp130 ... See more keywords

Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells

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recommendations! Published in 2019 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2019.01532

Abstract: The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies… read more here.

Keywords: treg cells; human treg; foxp3; function ... See more keywords
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CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients

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recommendations! Published in 2021 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2021.675250

Abstract: The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2… read more here.

Keywords: cd3 cd4; il6st expression; sle patients; gp130 ... See more keywords

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23137089

Abstract: N-acetyl-p-aminophenol (APAP)-induced liver damage is associated with upregulation of Interleukin-11 (IL11), which is thought to stimulate IL6ST (gp130)-mediated STAT3 activity in hepatocytes, as a compensatory response. However, recent studies have found IL11/IL11RA/gp130 signaling to be… read more here.

Keywords: il11; liver injury; apap induced; induced liver ... See more keywords

Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation.

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recommendations! Published in 2023 at "Journal of immunology"

DOI: 10.4049/jimmunol.2200461

Abstract: IL-6 plays a fundamental role in T cell differentiation and is strictly controlled by surface expression and shedding of IL-6R. IL-6 also acts on other cells that might affect T cell maturation. To study the… read more here.

Keywords: cell; lgp130; gp130 signaling; mice ... See more keywords