IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf4490
Abstract: Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here, we… read more here.
Keywords: human hepatocytes; accumulation; humanized liver; gp130 signaling ... See more keywords
Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200461
Abstract: IL-6 plays a fundamental role in T cell differentiation and is strictly controlled by surface expression and shedding of IL-6R. IL-6 also acts on other cells that might affect T cell maturation. To study the… read more here.
Keywords: cell; lgp130; gp130 signaling; mice ... See more keywords