DNA adjuvant Amiloride conjunct long immunization interval promote higher antibody responses to HIV-1 gp41 and gp140 immunogens.
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DOI: 10.1016/j.vaccine.2020.09.077
Abstract: Recent studies have revealed that the interface of gp120 and gp41 and some parts of gp41 are also critical epitopes for elicitation of broadly neutralizing antibodies. Therefore, potential trimeric gp41 or gp140 immunogen candidates are… read more here.
Keywords: immunization; gp140; gp41; long immunization ... See more keywords
Development of a synthetic nanoparticle vaccine presenting the HIV-1 envelope glycoprotein
Sign Up to like & getrecommendations! Published in 2022 at "Nanotechnology"
DOI: 10.1088/1361-6528/ac842c
Abstract: Two-component self-assembling virus-like particles (VLPs) are promising scaffolds for achieving high-density display of HIV-1 envelope (gp140) trimers, which can improve the induction of neutralising antibodies (NAbs). In this study gp140 was displayed on the surface… read more here.
Keywords: nanoparticle; gp140; coupled vlps; hiv envelope ... See more keywords