Conformational and lipid bilayer-perturbing properties of Marburg virus GP2 segments containing the fusion loop and membrane-proximal external region/transmembrane domain
Sign Up to like & getrecommendations! Published in 2019 at "Heliyon"
DOI: 10.1016/j.heliyon.2019.e03018
Abstract: Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined “class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the… read more here.
Keywords: marburg virus; gp2; membrane proximal; fusion ... See more keywords
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cell reports"
DOI: 10.1016/j.stemcr.2022.03.004
Abstract: Human pluripotent stem cell (hPSC)-derived pancreatic progenitors (PPs) can be differentiated into beta-like cells in vitro and in vivo and therefore have therapeutic potential for type 1 diabetes (T1D) treatment. However, the purity of PPs varies across… read more here.
Keywords: gp2 enriched; gp2; pancreatic progenitors; give rise ... See more keywords
Exploring the potential of T7 bacteriophage protein Gp2 as a novel inhibitor of mycobacterial RNA polymerase.
Sign Up to like & getrecommendations! Published in 2017 at "Tuberculosis"
DOI: 10.1016/j.tube.2017.07.004
Abstract: Over the past six decades, there has been a decline in novel therapies to treat tuberculosis, while the causative agent of this disease has become increasingly resistant to current treatment regimens. Bacteriophages (phages) are able… read more here.
Keywords: protein; exploring potential; gp2; rna polymerase ... See more keywords
Engineered Charge Redistribution of Gp2 Proteins through Guided Diversity for Improved PET Imaging of Epidermal Growth Factor Receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00144
Abstract: The Gp2 domain is a protein scaffold for synthetic ligand engineering. However, the native protein function results in a heterogeneous distribution of charge on the conserved surface, which may hinder further development and utility. We… read more here.
Keywords: gp2; charge; factor receptor; growth factor ... See more keywords
MdbZIP44–MdCPRF2-like–Mdα-GP2 regulate starch and sugar metabolism in apple under nitrogen supply
Sign Up to like & getrecommendations! Published in 2024 at "Horticulture Research"
DOI: 10.1093/hr/uhae072
Abstract: Abstract Nitrogen (N) is regarded as an essential macronutrient and is tightly associated with carbon (C) metabolism in plants. The transcriptome data obtained from this study showed that the expression level of the apple basic… read more here.
Keywords: nitrogen supply; mdcprf2 like; gp2; apple ... See more keywords
Abstract P5-07-22: Phase III study to evaluate the efficacy and safety of GLSI-100 (GP2 + GM-CSF) in breast cancer patients with residual disease or high-risk PCR after both neo-adjuvant and postoperative adjuvant anti-HER2 therapy, Flamingo-01
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.sabcs24-p5-07-22
Abstract: Background: GP2 is a biologic nine amino acid peptide of the HER2/neu protein delivered in combination with Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) that stimulates an immune response targeting HER2/neu expressing cancers, the combination known as… read more here.
Keywords: breast cancer; therapy; glsi 100; gp2 ... See more keywords
Minimum time optimal control simulation of a GP2 race car
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering"
DOI: 10.1177/0954407017728158
Abstract: In this work, optimal control theory is applied to minimum lap time simulation of a GP2 car, using a multibody car model with enhanced load transfer dynamics. The mathematical multibody model is formulated with use… read more here.
Keywords: gp2; time; simulation; car ... See more keywords
Tunable expression rate control of a growth-decoupled T7 expression system by l-arabinose only
Sign Up to like & getrecommendations! Published in 2021 at "Microbial Cell Factories"
DOI: 10.1186/s12934-021-01512-7
Abstract: Background Precise regulation of gene expression is of utmost importance for the production of complex membrane proteins (MP), enzymes or other proteins toxic to the host cell. In this article we show that genes under… read more here.
Keywords: production; gp2; system; expression ... See more keywords
Structure of human glycoprotein 2 reveals mechanisms underlying filament formation and adaption to proteolytic environment in the digestive tract
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3003238
Abstract: Glycoprotein 2 (GP2) and Uromodulin (UMOD) are considered as paralogs that share high sequence similarity and have similar antibacterial functions. UMOD are abundant as filaments in the urinary tract, and a high-mannose N-glycosylation site located… read more here.
Keywords: structure; tract; digestive tract; gp2 ... See more keywords
Conjugated nanoliposome with the HER2/neu-derived peptide GP2 as an effective vaccine against breast cancer in mice xenograft model
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185099
Abstract: One of the challenging issues in vaccine development is peptide and adjuvant delivery into target cells. In this study, we developed a vaccine and therapeutic delivery system to increase cytotoxic T lymphocyte (CTL) response against… read more here.
Keywords: dope; her2 neu; gp2; dope mpl ... See more keywords
Common Variants in NUS1 and GP2 Genes Contributed to the Risk of Gestational Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.685524
Abstract: Background Recently, NUS1 and GP2 genes were reported to be associated with the risk of type 2 diabetes (T2D) in a Japanese population. Given the sharing of pathogenic contribution from genetic factors between T2D and… read more here.
Keywords: gestational diabetes; risk; nus1 gp2; gp2 ... See more keywords