Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread.
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DOI: 10.1126/scitranslmed.adq5928
Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a priority pathogen transmitted by tick bites, with no vaccines or specific therapeutics approved to date. Severe disease manifestations include hemorrhage, endothelial dysfunction, and multiorgan failure. Infected cells release… read more here.
Keywords: hemorrhagic fever; congo hemorrhagic; fever virus; gp38 ... See more keywords
Immunogenicity of NSDV GP38 and the role of furin in GP38 proteolytic processing
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DOI: 10.1128/jvi.00537-25
Abstract: ABSTRACT Nairobi sheep disease virus (NSDV) is a tick-borne orthonairovirus, which is genetically related to Crimean-Congo hemorrhagic fever virus (CCHFV), and causes severe hemorrhagic gastroenteritis in infected sheep. CCHFV GP38, a cleavage product of the… read more here.
Keywords: role; gp38; nsdv gp38; immunogenicity nsdv ... See more keywords
Characterization of the Second Apoptosis Inhibitor Encoded by Guinea Pig Cytomegalovirus
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DOI: 10.1128/jvi.01622-22
Abstract: Although GPCMV provides a useful animal model for studies on the pathogenesis of congenital CMV infection and the development of CMV vaccine strategies, our understanding of the viral mechanisms by which it evades apoptosis of… read more here.
Keywords: guinea pig; apoptosis inhibitor; apoptosis; gp38 ... See more keywords