LILRB4 promotes tumor metastasis by regulating MDSCs and inhibiting miR-1 family miRNAs
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2060907
Abstract: ABSTRACT Myeloid-derived suppressor cells (MDSCs) are a population of immune suppressive cells that are involved in tumor-associated immunosuppression, and dominate tumor progression and metastasis. In this study, we report that the leukocyte immunoglobulin-like receptor subfamily… read more here.
Keywords: metastasis; mir family; gp49b; tumor ... See more keywords
Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac023
Abstract: LILRB4 (B4, also known as ILT3/CD85k) is an immune checkpoint of myeloid-lineage cells, albeit its mode of function remains obscure. Our recent identification of a common ligand for both human B4 and its murine ortholog… read more here.
Keywords: immune checkpoint; lilrb4; integrin; tether fibronectin ... See more keywords