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   Articles with "gp63" as a keyword



GP63 Alters the Macrophage Golgin160-Associated PIST Distribution by Reducing Caspase-3 Expression during Leishmania major Infection.

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recommendations! Published in 2025 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.5c00531

Abstract: Leishmania major, an intracellular protozoan parasite, resides within parasitophorous vacuoles in host macrophages and relies on host-pathway manipulation for survival. Here, we uncover a novel role of the Leishmania surface metalloprotease GP63 in stabilizing the… read more here.

Keywords: parasitophorous vacuoles; leishmania major; leishmania; gp63 ... See more keywords

Function of bacteriophage G7C esterase tailspike in host cell adsorption

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recommendations! Published in 2017 at "Molecular Microbiology"

DOI: 10.1111/mmi.13710

Abstract: Bacteriophages recognize and bind to their hosts with the help of receptor‐binding proteins (RBPs) that emanate from the phage particle in the form of fibers or tailspikes. RBPs show a great variability in their shapes,… read more here.

Keywords: function bacteriophage; gp63 gp66; gp63; host ... See more keywords

The role of Leishmania GP63 in the modulation of innate inflammatory response to Leishmania major infection

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recommendations! Published in 2021 at "PLoS ONE"

DOI: 10.1371/journal.pone.0262158

Abstract: Leishmaniasis is a disease caused by the protozoan parasite Leishmania and is known to affect millions of individuals worldwide. In recent years, we have established the critical role played by Leishmania zinc-metalloprotease GP63 in the… read more here.

Keywords: gp63; leishmania; innate inflammatory; leishmania gp63 ... See more keywords

Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates

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recommendations! Published in 2022 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1010640

Abstract: Colonization of host phagocytic cells by Leishmania metacyclic promastigotes involves several parasite effectors, including the zinc-dependent metalloprotease GP63. The major mode of action of this virulence factor entails the cleavage/degradation of host cell proteins. Given… read more here.

Keywords: gp63; leishmania; activity; host ... See more keywords

Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity

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recommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2022.803048

Abstract: Visceral leishmaniasis (VL) and post kala-azar dermal leishmaniasis (PKDL) affect most of the poor populations worldwide. The current treatment modalities include liposomal formulation or deoxycholate salt of amphotericin B, which has been associated with various… read more here.

Keywords: gp63; glycoside; activity; antileishmanial activity ... See more keywords