Conformational Dynamics and Allostery in E2:E3 Interactions Drive Ubiquitination: gp78 and Ube2g2.
Sign Up to like & getrecommendations! Published in 2017 at "Structure"
DOI: 10.1016/j.str.2017.03.016
Abstract: Conformational dynamics plays a fundamental role in molecular recognition and activity in enzymes. The ubiquitin-conjugating enzyme (E2) Ube2g2 functions with the ubiquitin ligase (E3) gp78 to assemble poly-ubiquitin chains on target substrates. Two domains in… read more here.
Keywords: conformational dynamics; interactions drive; allostery interactions; dynamics allostery ... See more keywords
Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00947-8
Abstract: The NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome plays a pivotal role in defending the host against infection as well as sterile inflammation. Activation of the NLRP3 inflammasome is critically regulated by a… read more here.
Keywords: inflammasome activation; nlrp3 inflammasome; ubiquitination; gp78 ... See more keywords