THU0301 Safety following initiation of rituximab in granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA): interim analysis of the rituximab in anca-associated vasculitis registry (RAVER)
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DOI: 10.1136/annrheumdis-2017-eular.1177
Abstract: Background Therapy-related serious adverse events (SAEs) are important causes of morbidity in patients with GPA or MPA. Long-term safety data of rituximab in GPA/MPA are limited. Objectives To characterize safety events in an observational registry… read more here.
Keywords: rituximab; none declared; gpa mpa; safety ... See more keywords
THU0463 Complement factors of the alternative pathway in gpa and mpa
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DOI: 10.1136/annrheumdis-2018-eular.3384
Abstract: Background In antineutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV), involvement of complements, especially alternative pathway of complement, has been reported in researches using mouse models. In human, while some studies have identified levels of C3 as… read more here.
Keywords: gpa mpa; complement; factor; mpa ... See more keywords
Dysregulated Responsiveness of Circulating Dendritic Cells to Toll-Like Receptors in ANCA-Associated Vasculitis
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DOI: 10.3389/fimmu.2017.00102
Abstract: Objective Dendritic cells (DCs) are critical effectors of innate and adaptive immunity playing crucial roles in autoimmune responses. We previously showed that blood DC numbers were reduced in autoimmune antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV). Here,… read more here.
Keywords: toll like; gpa mpa; dendritic cells; blood ... See more keywords