Structural basis of GPBAR activation and bile acid recognition
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2569-1
Abstract: The G-protein-coupled bile acid receptor (GPBAR) conveys the cross-membrane signalling of a vast variety of bile acids and is a signalling hub in the liver–bile acid–microbiota–metabolism axis 1 – 3 . Here we report the… read more here.
Keywords: microscopy; bile acid; acid recognition; gpbar ... See more keywords
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity
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DOI: 10.1073/pnas.2117054119
Abstract: Significance The G protein–coupled bile acid receptor (GPBAR) is the native bile acid receptor and therapeutic target for treating metabolic diseases. However, specific bile acids are suspected to promote cancer progression. We showed that different… read more here.
Keywords: cell; cell growth; nsclc cell; gpbar ... See more keywords