The Role of Glypican-1 in the Tumour Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-40146-7_8
Abstract: Glypican-1 (GPC-1) is a cell surface heparan sulphate proteoglycan that is critical during normal development, but which is not required for normal homoeostasis in the adult. It is, however, overexpressed in a variety of solid… read more here.
Keywords: role; tumour microenvironment; biology; gpc ... See more keywords
Validation of the effects of the Gpc-B1 high grain protein concentration locus from Lillian hard red spring wheat (Triticum aestivum L.) using locus specific markers
Sign Up to like & getrecommendations! Published in 2018 at "Euphytica"
DOI: 10.1007/s10681-018-2322-0
Abstract: Wheat grain protein concentration (GPC) is negatively associated with economic grain yield (GY) hindering attempts to improve these traits simultaneously. Studies indicate the incorporation of the Gpc-B1 high grain protein gene from emmer wheat into… read more here.
Keywords: grain protein; wheat; protein concentration; gpc ... See more keywords
Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.07.020
Abstract: Lassa virus (LASV) causes hemorrhagic fever and is endemic in West Africa. Protective antibody responses primarily target the LASV surface glycoprotein (GPC), and GPC-B competition group antibodies often show potent neutralizing activity in humans. However,… read more here.
Keywords: antibody; convergent structures; neutralization; gpc ... See more keywords
Estimating genetic variation and genetic parameters for grain iron, zinc and protein concentrations in bread wheat genotypes grown in Iran
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cereal Science"
DOI: 10.1016/j.jcs.2018.01.009
Abstract: Abstract The low grain micronutrient concentrations particularly iron and zinc are well documented problems in wheat. Eighty bread wheat genotypes were assessed for grain iron (GFeC), zinc (GZnC) and protein (GPC) concentrations along with agronomic… read more here.
Keywords: wheat genotypes; zinc; iron zinc; gpc ... See more keywords
Exposure of carbendazim induces structural and functional alteration in garlic phytocystatin: An in vitro multi-spectroscopic approach.
Sign Up to like & getrecommendations! Published in 2018 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2018.01.008
Abstract: Carbendazim is a broad spectrum benzimidazole fungicide which is used to ensure plants' protection from pest and pathogens' invasion. The present work describes the impact of carbendazim (CAR) on garlic phytocystatin (GPC) which is a… read more here.
Keywords: carbendazim; alteration; structural functional; gpc ... See more keywords
Clinical development of an anti-GPC-1 antibody for the treatment of cancer
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2033204
Abstract: ABSTRACT Introduction Glypican-1 (GPC-1) is a heparan sulfate proteoglycan (HSPG) overexpressed in multiple cancers. Multiple studies indicate the prominence of this cancer biomarker with significant diagnostic and therapeutic potential. Recent advances in monoclonal antibody (mAb)-based… read more here.
Keywords: anti gpc; gpc; gpc antibody; clinical development ... See more keywords
A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq0991
Abstract: Developing potent therapeutics and effective vaccines are the ultimate goals in controlling infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects hundreds of thousands annually, but effective antivirals or vaccines against… read more here.
Keywords: glycan shield; lassa virus; protective antibodies; cocktail ... See more keywords
Structure-Based Classification Defines the Discrete Conformational Classes Adopted by the Arenaviral GP1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01048-18
Abstract: The genetically and geographically diverse group of viruses within the family Arenaviridae includes a number of zoonotic pathogens capable of causing fatal hemorrhagic fever. The multisubunit GPC glycoprotein spike complex displayed on the arenavirus envelope… read more here.
Keywords: structure based; gpc; world; gp1 ... See more keywords
Differences in Glycoprotein Complex Receptor Binding Site Accessibility Prompt Poor Cross-Reactivity of Neutralizing Antibodies between Closely Related Arenaviruses
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01454-16
Abstract: ABSTRACT The glycoprotein complex (GPC) of arenaviruses, composed of stable signal peptide, GP1, and GP2, is the only antigen correlated with antibody-mediated neutralization. However, despite strong cross-reactivity of convalescent antisera between related arenavirus species, weak… read more here.
Keywords: junv; macv; neutralizing antibodies; gpc ... See more keywords
Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003441
Abstract: Background Glypican-3 (GPC-3) is an oncofetal protein that is highly expressed in various solid tumors, but rarely expressed in healthy adult tissues and represents a rational target of particular relevance in hepatocellular carcinoma (HCC). Autologous… read more here.
Keywords: gpc; antigen; gpc car; cell ... See more keywords
Calibration of a stress-strain response for geopolymer concrete under axial compressive load
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications"
DOI: 10.1177/14644207221075912
Abstract: The use of geopolymer concrete (GPC) in common load-bearing structures is still limited, mainly due to the lack of specific design procedures and limited understanding of the stress–strain behavior under uniaxial loading. The present work… read more here.
Keywords: stress; stress strain; load; strain ... See more keywords