Machupo Virus with Mutations in the Transmembrane Domain and Glycosylation Sites of the Glycoprotein Is Attenuated and Immunogenic in Animal Models of Bolivian Hemorrhagic Fever
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DOI: 10.1128/jvi.00209-22
Abstract: For arenaviruses, the only vaccine available is the live attenuated Candid#1 vaccine, a JUNV vaccine approved in Argentina. We and others have found that the glycans on GPC and the F427 residue in the GPC… read more here.
Keywords: macv; gpc tmd; glycosylation sites; vaccine ... See more keywords