Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells
Sign Up to like & getrecommendations! Published in 2023 at "Glycobiology"
DOI: 10.1093/glycob/cwad013
Abstract: Abstract In Parkinson’s disease, there is an accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. In neural cells, cytokine-induced SYN aggregation is modulated by heparan sulfate (HS) derived from glypican-1 (GPC1)… read more here.
Keywords: aggregation; processing; interplay app; synfil ... See more keywords
miR‐143‐3p/TET1 Axis Regulates GPC1 Through DNA Methylation and Impairs the Malignant Biological Behaviour of HCC via the Hippo Signalling Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70282
Abstract: Hepatocellular carcinoma (HCC) is a malignant tumour that poses a serious threat to human health and places a heavy burden on individuals and society. However, the role of GPC1 in the malignant progression of HCC… read more here.
Keywords: methylation; dna methylation; hcc; mir 143 ... See more keywords
GPC1-targeted immunotoxins inhibit pancreatic tumor growth in mice via depletion of short-lived GPC1 and downregulation of Wnt signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0778
Abstract: Glypican-1 (GPC1) is a cell surface proteoglycan that is upregulated in multiple types of human cancers including pancreatic cancer. Here, we investigated whether GPC1 could be a target of antibody-toxin fusion proteins (i.e. immunotoxins) for… read more here.
Keywords: tumor growth; gpc1 targeted; immunotoxin; gpc1 ... See more keywords
Abstract 907: Evaluation of the anti-GPC1 scFv-Fc fusion protein as a detection tool of GPC1 expression in human cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-907
Abstract: Background: We have developed a glypican-1 (GPC1) targeted CAR-T cell with strong anti-tumor effects against solid tumors in vivo (Kato et al 2020 eLife). In general, an antibody is used for detection of target protein… read more here.
Keywords: cell; scfv fusion; anti gpc1; gpc1 ... See more keywords
Abstract 1559: Assessing efficacy of anti-glypican-1antibody-drug conjugate as potential therapeutic approach for gastric cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1559
Abstract: Despite significant advancements in cancer treatment, gastric cancer (GC) still has a high incidence and mortality rate. Antibody-drug conjugates (ADCs) are emerging as viable treatment option for GC. We previously identified glypican-1 (GPC1) as a… read more here.
Keywords: cancer; gpc1 adc; efficacy; cell ... See more keywords
Abstract 1913: Role of glypican 1 in regulating fibroblast activation in the prostate cancer tumor microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-1913
Abstract: Cancer is a heterogeneous collection of neoplastic cells, surrounded by non-malignant, stromal cells, and extracellular matrix (ECM), among other constituents. Cross-talk between tumor and stromal cells forms a dynamic tumor microenvironment (TME) that mediates cell… read more here.
Keywords: role; cancer; prostate cancer; tumor ... See more keywords
GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269094
Abstract: In this study, we analyzed GPC family genes in colorectal cancer (CRC) and the possible mechanism of action of GPC1 in CRC. CRC patient data were extracted from The Cancer Genome Atlas, and the prognostic… read more here.
Keywords: signaling pathway; crc; smad2; gpc1 ... See more keywords
The clinical significance of circulating GPC1 positive exosomes and its regulative miRNAs in colon cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20516
Abstract: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Recent study found an increased level of glypican-1 positive (GPC1+) plasma exosomes in patients with stage II CRC, but decreased levels of plasma miR-96-5p… read more here.
Keywords: mir 149; mir mir; colon cancer; cancer ... See more keywords
Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/β-catenin pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-240
Abstract: Background Glypican 1 (GPC1) is a heparan sulphate proteoglycan cell membrane protein. It is implicated in driving cancers of the breast, brain, pancreas, and prostate; however, its role in esophagogastric cancer (EGAC) remains unexplored. The… read more here.
Keywords: catenin; akt gsk; gpc1; gsk catenin ... See more keywords