GPC1-targeted immunotoxins inhibit pancreatic tumor growth in mice via depletion of short-lived GPC1 and downregulation of Wnt signaling.
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DOI: 10.1158/1535-7163.mct-21-0778
Abstract: Glypican-1 (GPC1) is a cell surface proteoglycan that is upregulated in multiple types of human cancers including pancreatic cancer. Here, we investigated whether GPC1 could be a target of antibody-toxin fusion proteins (i.e. immunotoxins) for… read more here.
Keywords: tumor growth; gpc1 targeted; immunotoxin; gpc1 ... See more keywords