Identification of a Glypican-3-Binding Peptide for In Vivo Non-Invasive Human Hepatocellular Carcinoma Detection.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201600335
Abstract: Early and accurate detection of hepatocellular carcinoma (HCC) is essential to improve the prognosis of patients and reduce the morbidity of surgical therapy. Glypican-3 (GPC3) is a protein abnormally expressed in HCC that has been… read more here.
Keywords: hepatocellular carcinoma; detection; hcc; peptide ... See more keywords
Evaluating antitumor activity of antiglypican-3 therapy in experimentally induced skin cancer in mice
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-020-02102-0
Abstract: Abstract Glypican-3 (GPC3) is considered as a cell surface heparan sulfate proteoglycan. It is overexpressed in skin cancer and promotes tumor progression and pathogenicity. Therefore, we aimed to find out the therapeutic effects of immuno-suppressing… read more here.
Keywords: experimentally induced; skin cancer; mice; cancer ... See more keywords
Significance of Glypican-3 in Early Detection of Hepatocellular Carcinoma in Cirrhotic Patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastrointestinal Cancer"
DOI: 10.1007/s12029-018-0095-2
Abstract: BackgroundEgypt has high incidence of hepatocellular carcinoma (HCC). This is due to wide spread of hepatitis C virus (HCV) infection which is responsible for most of the cases of liver cirrhosis. The major diagnostic techniques… read more here.
Keywords: hepatocellular carcinoma; hcc; cirrhotic patients; significance ... See more keywords
Redirecting T cells to glypican-3 with 28.41BB.ζ and 28.ζ-41BBL CARs for hepatocellular carcinoma treatment
Sign Up to like & getrecommendations! Published in 2017 at "Protein & Cell"
DOI: 10.1007/s13238-017-0489-0
Abstract: T cells genetically engineered to express CARs specific for CD19 have shown breakthrough clinical successes in patients with B-cell lymphoid malignancies in recent years (Grupp SA et al., 2013; Kalos M et al., 2011; Maude… read more here.
Keywords: gpc3 car; car cells; gpc3; cell ... See more keywords
Simultaneous Homogeneous Fluorescence Detection of AFP and GPC3 in Hepatocellular Carcinoma Clinical Samples Assisted by Enzyme-Free Catalytic Hairpin Assembly.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c09135
Abstract: Simultaneous sensitive and cost-effective detection of multiple tumor markers has shown great potential for cancer diagnostics. Herein, we reported a simple enzyme-free parallel catalytic hairpin assembly (CHA) amplification strategy with N-methyl mesoporphyrin IX (NMM) and… read more here.
Keywords: enzyme free; hairpin assembly; detection; afp gpc3 ... See more keywords
An innovative peptide with high affinity to GPC3 for hepatocellular carcinoma diagnosis.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c8bm01016a
Abstract: Glypican-3 (GPC3) is a key biomarker for early diagnosis of human hepatocellular carcinoma (HCC) due to its overexpression in most HCC tumor tissues. Recently, peptides with high affinity to GPC3 have attracted more attention because… read more here.
Keywords: hepatocellular carcinoma; high affinity; diagnosis; affinity gpc3 ... See more keywords
Frequently expressed glypican‐3 as a promising novel therapeutic target for osteosarcomas
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15521
Abstract: Osteosarcoma (OS) is the most common bone malignancy without a reliable therapeutic target. Glypican‐3 (GPC3) mutation and upregulation have been detected in multidrug resistant OS, and anti‐GPC3 immunotherapy can effectively suppress the growth of organoids.… read more here.
Keywords: therapeutic target; anti gpc3; cd133; expression ... See more keywords
Are all Xq26.2 duplications overlapping GPC3 on array‐CGH a cause of Simpson‐Golabi‐Behmel syndrome? When do we need transcript analysis?
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Genetics"
DOI: 10.1111/cge.13151
Abstract: To the Editor: Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked multiple congenital anomalies (MCA) and overgrowth syndrome caused by a lossof-function of the glypican-3 gene (GPC3). Almost, a hundred distinct GPC3mutations have been identified, mostly large… read more here.
Keywords: analysis; gpc3; array cgh; duplication ... See more keywords
Structural and functional impact of post-translation modification of GPC3 on liver carcinogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3895
Abstract: Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in hepatocellular carcinoma. GPC3 undergoes extensive post-translational modification including cleavage and glycosylation. This review focuses on the structure and function of GPC3 in liver cancer,… read more here.
Keywords: modification; gpc3; post translation; gpc3 liver ... See more keywords
Abstract 4508: Glypican-3 (GPC3) signaling pathway involved in breast cancer progression
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4508
Abstract: GPC3 is a proteoglycan downregulated in breast tumors. Employing LM3 murine mammary adenocarcinoma cell line (ER-, PR-), we have previously shown that GPC3 acts as a metastasis suppressor and induces a reversion of the epithelial… read more here.
Keywords: wnt; breast; canonical wnt; non canonical ... See more keywords
Abstract CT097: First report of preliminary safety, efficacy, and pharmacokinetics of C-CAR031 (GPC3-specific TGFβRIIDN CAR-T) in patients with advanced HCC
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct097
Abstract: Introduction: Chimeric antigen receptor (CAR) T cells can mediate deep and durable responses in hematologic malignancies, however, achieving success in solid tumors has been so far limited largely by lack of suitable solid tumor-associated antigens… read more here.
Keywords: safety; car; efficacy; tgf riidn ... See more keywords