Circulating Glypican-4 Is a Predictor of 24-Month Overall Survival in Metastatic Breast Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Oncology Research and Treatment"
DOI: 10.1159/000529547
Abstract: Introduction: Endocrine treatment combined with CDK4/6 inhibitors is the preferred treatment strategy in patients presenting with ER-positive/HER2-negative breast cancer, but the clinical course remains highly variable among individual patients. There is an unmet need for… read more here.
Keywords: circulating glypican; breast cancer; gpc4; metastatic breast ... See more keywords
Heparan Sulfated Glypican-4 Is Released from Astrocytes by Proteolytic Shedding and GPI-Anchor Cleavage Mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "eNeuro"
DOI: 10.1523/eneuro.0069-21.2021
Abstract: Visual Abstract Astrocytes provide neurons with diffusible factors that promote synapse formation and maturation. In particular, glypican-4/GPC4 released from astrocytes promotes the maturation of excitatory synapses. Unlike other secreted factors, GPC4 contains the C-terminal GPI-anchorage… read more here.
Keywords: proteolytic shedding; gpi anchor; gpc4; release ... See more keywords
Circulating syndecan-1 and glypican-4 predict 12-month survival in metastatic colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1045995
Abstract: Cell surface syndecans and glypicans play important roles in the development and prognosis of colorectal cancer (CRC). Their soluble forms from proteoglycan shedding can be detected in blood and have been proposed as new prognostic… read more here.
Keywords: circulating syndecan; sdc1 gpc4; colorectal cancer; gpc4 ... See more keywords