GPCR Signaling From Intracellular Membranes − A Novel Concept
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700200
Abstract: The properties of the main psychoactive compound of the Cannabis plant, namely Δ-tetrahydrocannabinol (THC), have been recognized for a long time. Ever since the discovery of cannabinoid receptors (CB1R and CB2R) and the characterization of… read more here.
Keywords: intracellular membranes; gpcr signaling; concept gpcr; gpcr ... See more keywords
GPCR Signaling Regulation in Dictyostelium Chemotaxis.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1258-3_27
Abstract: GPCR signaling is the most prevailing molecular mechanism for detecting ambient signals in eukaryotes. Chemotactic cells use GPCR signaling to process chemical cues for directional migration over a broad concentration range and with high sensitivity.… read more here.
Keywords: regulation dictyostelium; signaling regulation; gpcr signaling; gpcr ... See more keywords
Co-IP assays for measuring GPCR-arrestin interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2018.09.003
Abstract: βarrestin1 and -2 (also known as arrestin2 and -3, respectively) are G protein-coupled receptor (GPCR) adapter proteins, performing three major functions in the cell: functional desensitization, i.e., G protein uncoupling from the receptor, GPCR internalization… read more here.
Keywords: gpcr arrestin; gpcr; measuring gpcr; assays measuring ... See more keywords
GPCR mediated control of calcium dynamics: A systems perspective
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Signalling"
DOI: 10.1016/j.cellsig.2020.109717
Abstract: Abstract G-protein coupled receptor (GPCR) mediated calcium (Ca2+)-signaling transduction remains crucial in designing drugs for various complex diseases including neurodegeneration, chronic heart failure as well as respiratory diseases. Although there are several reviews detailing various… read more here.
Keywords: systems perspective; control; ca2 signaling; gpcr ... See more keywords
Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.11.023
Abstract: Summary Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially restricted between early… read more here.
Keywords: integration gpcr; signaling sorting; gpcr signaling; gpcr ... See more keywords
Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b11422
Abstract: Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and spatial precision are in great demand. Photopharmacology uses photons to control in situ the biological properties of photoswitchable small-molecule ligands, which bodes well for… read more here.
Keywords: gpcr; antagonist toolbox; real time; photopharmacology ... See more keywords
Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15700
Abstract: G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR expression analysis in… read more here.
Keywords: single cell; gpcr; heterogeneity functional; gpcr expression ... See more keywords
Combinatorial expression of GPCR isoforms affects signalling and drug responses
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2888-2
Abstract: G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across human tissues in response to extracellular signals. GPCR-mediated signalling can differ because of changes in the sequence 1 , 2 or expression 3 of the… read more here.
Keywords: drug responses; combinatorial expression; gpcr isoforms; gpcr ... See more keywords
Visualizing the GPCR Network: Classification and Evolution
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15707-9
Abstract: In this study, we delineate an unsupervised clustering algorithm, minimum span clustering (MSC), and apply it to detect G-protein coupled receptor (GPCR) sequences and to study the GPCR network using a base dataset of 2770… read more here.
Keywords: classification; evolution; level; gpcr ... See more keywords
CaMello-XR enables visualization and optogenetic control of Gq/11 signals and receptor trafficking in GPCR-specific domains
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0292-y
Abstract: The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors (5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular signaling domain. Visualizing traffic-dependent GPCR signals in neurons is difficult, but… read more here.
Keywords: ca2 signals; gpcr; receptor trafficking; localization ... See more keywords
Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1911444117
Abstract: Significance While inflammatory chemokines, constitutively produced by pathologic regions, are pivotal for attracting reparative stem cells, one would certainly not want to further “inflame” a diseased brain by instilling such molecules. Exploiting the fact that… read more here.
Keywords: stem cell; migration; gpcr; stem ... See more keywords