Effects of Cholesterol on GPCR Function: Insights from Computational and Experimental Studies.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-14265-0_5
Abstract: The extensive experimental and computational evidences revealed that cholesterol is involved in the drug binding to G protein-coupled receptor (GPCR) targets that is influenced by the membrane environment and external functions. These multifunctional factors make… read more here.
Keywords: cholesterol gpcr; function insights; insights computational; gpcr function ... See more keywords
Structural bioinformatics analysis of variants on GPCR function.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.04.007
Abstract: G protein-coupled receptors (GPCRs) are key membrane-embedded receptor proteins, with critical roles in cellular signal transduction. In the era of precision medicine, understanding the role of natural variants on GPCR function is critical, especially from… read more here.
Keywords: medicine; gpcr function; variants gpcr; analysis variants ... See more keywords