Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer.
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DOI: 10.1073/pnas.2213140120
Abstract: Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely targeted by clinically approved drugs. However, it has become evident that heterotrimeric G-proteins can also be activated via… read more here.
Keywords: small molecule; gpcr independent; noncanonical protein; protein signaling ... See more keywords