GPCR mediated control of calcium dynamics: A systems perspective
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Signalling"
DOI: 10.1016/j.cellsig.2020.109717
Abstract: Abstract G-protein coupled receptor (GPCR) mediated calcium (Ca2+)-signaling transduction remains crucial in designing drugs for various complex diseases including neurodegeneration, chronic heart failure as well as respiratory diseases. Although there are several reviews detailing various… read more here.
Keywords: systems perspective; control; ca2 signaling; gpcr ... See more keywords
The integrin ligand SVEP1 regulates GPCR‐mediated vasoconstriction via integrins α9β1 and α4β1
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15921
Abstract: Vascular tone is regulated by the relative contractile state of vascular smooth muscle cells (VSMCs). Several integrins directly modulate VSMC contraction by regulating calcium influx through L‐type voltage‐gated Ca2+ channels (VGCCs). Genetic variants in ITGA9,… read more here.
Keywords: ligand svep1; svep1 regulates; regulates gpcr; integrin ligand ... See more keywords
GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade5397
Abstract: Chronic stress increases the risk of developing psychiatric disorders, including mood and anxiety disorders. Although behavioral responses to repeated stress vary across individuals, the underlying mechanisms remain unclear. Here, we perform a genome-wide transcriptome analysis… read more here.
Keywords: mediated calcium; stress; calcium camp; gpcr mediated ... See more keywords
Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8425640
Abstract: G protein-coupled receptors (GPCRs) are intricately involved in the conversion of extracellular feedback to intracellular responses. These specialized receptors possess a crucial role in neurological and psychiatric disorders. Most nonsensory GPCRs are active in almost… read more here.
Keywords: protein gpcr; mediated signaling; regulation; gpcr mediated ... See more keywords
GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008419
Abstract: Microorganisms sense environmental fluctuations in nutrients and light, coordinating their growth and development accordingly. Despite their critical roles in fungi, only a few G-protein coupled receptors (GPCRs) have been characterized. The Aspergillus nidulans genome encodes… read more here.
Keywords: production; glucose sensing; light dependent; gpcr mediated ... See more keywords
Ras inhibitors gate chemoattractant concentration range for chemotaxis through controlling GPCR-mediated adaptation and cell sensitivity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1020117
Abstract: Chemotaxis plays an essential role in recruitment of leukocytes to sites of inflammation. Eukaryotic cells sense chemoattractant with G protein-coupled receptors (GPCRs) and chemotax toward gradients with an enormous concentration range through adaptation. Cells in… read more here.
Keywords: mediated adaptation; adaptation; concentration range; gpcr mediated ... See more keywords
Examination of Intracellular GPCR-Mediated Signaling with High Temporal Resolution
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158516
Abstract: The GTP-binding protein-coupled receptors (GPCRs) play important roles in physiology and neuronal signaling. More than a thousand genes, excluding the olfactory receptors, have been identified that encode these integral membrane proteins. Their pharmacological and functional… read more here.
Keywords: examination intracellular; mediated signaling; signaling high; intracellular gpcr ... See more keywords