Exploring functional consequences of GPCR oligomerization requires a different lens.
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DOI: 10.1016/bs.pmbts.2019.11.001
Abstract: As the largest family of cell surface receptors, G protein-coupled receptors (GPCRs) represent an important strategic class of therapeutic targets. Attaining a clearer perspective of how such signaling complexes set molecular events in motion could… read more here.
Keywords: consequences gpcr; requires different; gpcr oligomerization; functional consequences ... See more keywords
Luminescence- and Fluorescence-Based Complementation Assays to Screen for GPCR Oligomerization: Current State of the Art
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DOI: 10.3390/ijms20122958
Abstract: G protein-coupled receptors (GPCRs) have the propensity to form homo- and heterodimers. Dysfunction of these dimers has been associated with multiple diseases, e.g., pre-eclampsia, schizophrenia, and depression, among others. Over the past two decades, considerable… read more here.
Keywords: gpcr oligomerization; complementation assays; complementation; gpcr gpcr ... See more keywords