GPCR Signaling From Intracellular Membranes − A Novel Concept
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700200
Abstract: The properties of the main psychoactive compound of the Cannabis plant, namely Δ-tetrahydrocannabinol (THC), have been recognized for a long time. Ever since the discovery of cannabinoid receptors (CB1R and CB2R) and the characterization of… read more here.
Keywords: intracellular membranes; gpcr signaling; concept gpcr; gpcr ... See more keywords
Luciferase Complementation Approaches to Measure GPCR Signaling Kinetics and Bias.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1221-7_17
Abstract: An understanding of the kinetic contributions to G protein-coupled receptor pharmacology and signaling is increasingly important in compound profiling. Nonequilibrium conditions are commonly present in vivo, for example, as the drug competes with dynamic changes… read more here.
Keywords: complementation approaches; approaches measure; gpcr signaling; pharmacology ... See more keywords
GPCR Signaling Regulation in Dictyostelium Chemotaxis.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1258-3_27
Abstract: GPCR signaling is the most prevailing molecular mechanism for detecting ambient signals in eukaryotes. Chemotactic cells use GPCR signaling to process chemical cues for directional migration over a broad concentration range and with high sensitivity.… read more here.
Keywords: regulation dictyostelium; signaling regulation; gpcr signaling; gpcr ... See more keywords
Imaging of Tissue-Specific and Temporal Activation of GPCR Signaling Using DREADD Knock-In Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9121-1_21
Abstract: Engineered G protein-coupled receptors (DREADDs, designer receptors exclusively activated by designer drugs) are convenient tools for specific activation of GPCR signaling in many cell types. DREADDs have been utilized as research tools to study numerous… read more here.
Keywords: gpcr signaling; activation gpcr; knock mice; mice ... See more keywords
Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2019.12.005
Abstract: Key metabolites act through specific G protein-coupled receptors (GPCRs) as extracellular signals of fuel availability and metabolic stress. Here, we focus on the succinate receptor SUCNR1/GPR91 and the long chain fatty acid receptor FFAR1/GPR40, for… read more here.
Keywords: structural basis; basis gpcr; signaling small; small polar ... See more keywords
Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.11.023
Abstract: Summary Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially restricted between early… read more here.
Keywords: integration gpcr; signaling sorting; gpcr signaling; gpcr ... See more keywords
Pleiotropic GPCR signaling in health and disease
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.05.013
Abstract: This Special Issue of Molecular and Cellular Endocrinology on ‘Pleiotropic G protein-coupled receptor (GPCR) signaling in health and disease’ illustrates the exquisite complexity of GPCR signal systems, current approaches to decode this complexity and progress… read more here.
Keywords: signaling health; endocrinology; gpcr signaling; health disease ... See more keywords
Heterotrimeric G proteins regulate planarian regeneration and behavior
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyad019
Abstract: G protein-coupled receptors (GPCRs) play broad roles in development and stem cell biology, but few roles for GPCR signaling in complex tissue regeneration have been uncovered. Planarian flatworms robustly regenerate all tissues and provide a… read more here.
Keywords: regeneration; behavior; gpcr signaling; heterotrimeric proteins ... See more keywords
PRECOGx: exploring GPCR signaling mechanisms with deep protein representations
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac426
Abstract: Abstract In this study we show that protein language models can encode structural and functional information of GPCR sequences that can be used to predict their signaling and functional repertoire. We used the ESM1b protein… read more here.
Keywords: gpcr signaling; gpcr; signaling mechanisms; precogx exploring ... See more keywords
Pepducin-mediated GPCR signaling in the cardiovascular system.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001236
Abstract: ABSTRACT Pepducins are small-lipidated peptides designed from the intracellular loops (iLs) of G protein-coupled receptors (GPCRs) that act in an allosteric manner to modulate the activity of GPCRs. Over the last two decades, pepducins have… read more here.
Keywords: pepducin mediated; signaling cardiovascular; cardiovascular system; gpcr signaling ... See more keywords
GPCR signaling regulates severe stress‐induced organismic death in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13735
Abstract: How an organism dies is a fundamental yet poorly understood question in biology. An organism can die of many causes, including stress‐induced phenoptosis, also defined as organismic death that is regulated by its genome‐encoded programs.… read more here.
Keywords: stress; gpcr signaling; stress induced; organismic death ... See more keywords