Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2017.09.005
Abstract: Genetically encoded Förster resonance energy transfer (FRET) biosensors have been instrumental to our understanding of how intracellular signalling is organised and regulated within cells. In the last decade, the toolbox, dynamic range and applications of… read more here.
Keywords: genetically encoded; gpcr signalling; biosensors illuminate; fret biosensors ... See more keywords
Arrestins as rheostats of GPCR signalling
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0041-y
Abstract: G protein-coupled receptors (GPCRs) have a central role in a myriad of physiological functions and their dysregulation underlies some of the most prevalent human diseases. They control cell behaviour and cell fate by recruiting and… read more here.
Keywords: signalling arrestins; arrestins rheostats; rheostats gpcr; gpcr signalling ... See more keywords
Unravelling GPCR signalling networks using global phosphoproteomics.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16052
Abstract: GPCR activation initiates signalling via a complex network of intracellular effectors that combine to produce diverse cellular and tissue responses. Although we have an advanced understanding of the proximal events following receptor stimulation, the molecular… read more here.
Keywords: unravelling gpcr; networks using; signalling networks; global phosphoproteomics ... See more keywords