A robust antibody discovery platform for difficult‐to‐express G protein‐coupled receptors
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4520
Abstract: G protein‐coupled receptors (GPCRs) are in the spotlight as drug targets due to the fact that multiple research results have verified the correlation between the activation of GPCRs and disease indications. This is because the… read more here.
Keywords: difficult express; coupled receptors; gpcrs; protein coupled ... See more keywords
GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4751-9
Abstract: PurposeG protein-coupled receptors (GPCRs) represent the largest family of druggable targets in human genome. Although several GPCRs can cross-talk with the human epidermal growth factor receptors (HERs), the expression and function of most GPCRs remain… read more here.
Keywords: her2; breast cancer; gpcrs; her2 breast ... See more keywords
Cholesterol-dependent endocytosis of GPCRs: implications in pathophysiology and therapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical reviews"
DOI: 10.1007/s12551-021-00878-7
Abstract: G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins that relay extracellular signals across the plasma membrane and elicit an intricate cascade of cellular signaling events. A significantly large fraction of available drugs… read more here.
Keywords: dependent endocytosis; endocytosis gpcrs; membrane; gpcrs ... See more keywords
ERK Activation Pathways Downstream of GPCRs.
Sign Up to like & getrecommendations! Published in 2018 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.02.003
Abstract: GPCRs, the 7-TM receptors, represent a class of cell surface receptors which modulate a variety of physiological responses. The serpentine structure in addition to contributing the diversity of stimuli these receptors can sense also provides… read more here.
Keywords: erk activation; activation pathways; downstream gpcrs; activation ... See more keywords
Illuminating G-Protein-Coupling Selectivity of GPCRs
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.04.044
Abstract: Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence… read more here.
Keywords: illuminating protein; protein coupling; coupling selectivity; gpcrs ... See more keywords
Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.040
Abstract: Insulin secretion from pancreatic β cells is a highly complex and tightly regulated process. Its dysregulation is one characteristic of type 2 diabetes, and thus, an in-depth understanding of the mechanisms controlling insulin secretion is… read more here.
Keywords: insulin; involvement adhesion; insulin secretion; adhesion gpcrs ... See more keywords
Identification and characterization of pyrokinin and CAPA peptides, and corresponding GPCRs from spotted wing drosophila, Drosophila suzukii.
Sign Up to like & getrecommendations! Published in 2017 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.01.011
Abstract: The family of FXPRLamide peptides serves as a major insect hormone. It is characterized by a core active amino acid sequence conserved at the C-terminal ends, and provides various physiological roles across the Insecta. In… read more here.
Keywords: drosophila; capa; pyrokinin capa; receptor ... See more keywords
DAKB-GPCRs: An Integrated Computational Platform for Drug Abuse Related GPCRs
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00623
Abstract: Drug abuse (DA) or drug addiction is a complicated brain disorder which is commonly considered as neurobiological impairments caused by both genetic factors and environmental effects. Among DA-related targets, G protein-coupled receptors (GPCRs) play an… read more here.
Keywords: drug abuse; drug; dakb gpcrs; gpcrs integrated ... See more keywords
Anti-inflammatory signaling through G protein-coupled receptors.
Sign Up to like & getrecommendations! Published in 2020 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00523-1
Abstract: G protein-coupled receptors (GPCRs) play important roles in human physiology. GPCRs are involved in immunoregulation including regulation of the inflammatory response. Chemotaxis of phagocytes and lymphocytes is mediated to a great extent by the GPCRs… read more here.
Keywords: anti inflammatory; protein coupled; coupled receptors; gpcrs ... See more keywords
Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Data"
DOI: 10.1038/s41597-020-00729-2
Abstract: Structural studies of challenging targets such as G protein-coupled receptors (GPCRs) have accelerated during the last several years due to the development of new approaches, including small-wedge and serial crystallography. Here, we describe the deposition… read more here.
Keywords: cysteinyl leukotriene; wedge; small wedge; wedge synchrotron ... See more keywords
FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aar5536
Abstract: Ligand binding induces conformational changes in FZD5, activation of heterotrimeric G proteins, and Gq-dependent signaling. FZD5 as a prototypical GPCR Despite exhibiting sequence and structural similarity to other classes of G protein–coupled receptors (GPCRs), class… read more here.
Keywords: fzd5; class; gpcr; activation ... See more keywords