G protein-coupled estrogen receptor 1 (GPER-1) and agonist G-1 inhibit growth of ovarian cancer cells by activation of anti-tumoral transcriptome responses: impact of GPER-1 mRNA on survival
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03333-4
Abstract: The present study intended to further elucidate the role of G protein-coupled estrogen receptor 1 (GPER-1) in ovarian cancer by comparing the effects of a GPER-1 knockdown and treatment with its agonist G-1 on cell… read more here.
Keywords: cell; agonist; gper; ovarian cancer ... See more keywords
Contribution of G protein-coupled estrogen receptor 1 (GPER) to 17β-estradiol-induced developmental toxicity in zebrafish.
Sign Up to like & getrecommendations! Published in 2017 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2017.02.024
Abstract: Exposure to 17β-estradiol (E2) influences the regulation of multiple signaling pathways, and E2-mediated disruption of signaling events during early development can lead to malformations such as cardiac defects. In this study, we investigated the potential… read more here.
Keywords: hpf; gper; expression; receptor gper ... See more keywords
Bisphenol AF exerts estrogenic activity in MCF-7 cells through activation of Erk and PI3K/Akt signals via GPER signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.12.122
Abstract: The negative health effects of bisphenol A (BPA) due to its estrogenic activity result in the increasing usage of alternative bisphenols (BPs) including bisphenol AF (BPAF). To comprehensive understand health effects of BPAF, the MCF-7 cells… read more here.
Keywords: mcf cells; estrogenic activity; pi3k akt; gper ... See more keywords
MEHP promotes the proliferation of cervical cancer via GPER mediated activation of Akt
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.01.040
Abstract: &NA; Cervical cancer is the fourth leading cause of cancer death in females worldwide and the second leading cause of mortality among women. Estrogenic signals can regulate the progression of cervical cancer, however, little is… read more here.
Keywords: akt; cervical cancer; gper; activation ... See more keywords
Telocytes are localized to testis of the bank vole (Myodes glareolus) and are affected by lighting conditions and G-coupled membrane estrogen receptor (GPER) signaling.
Sign Up to like & getrecommendations! Published in 2019 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.10.021
Abstract: We aim to explore the presence of a novel cell type, telocytes (TCs), in the bank vole testis interstitium following G-coupled membrane estrogen receptor (GPER) signaling withdrawal. In addition, the involvement of interstitial cells in… read more here.
Keywords: testis; gper; membrane estrogen; bank vole ... See more keywords
Chronic GPER activation prompted the proliferation of ileal stem cell in ovariectomized mice depending on Paneth cell-derived Wnt3.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical science"
DOI: 10.1042/cs20220392
Abstract: Menopausal women often face long-term estrogen treatment. G protein-coupled estrogen receptor (GPER) expressed in intestinal crypt was activated by estrogen therapy, but it was unclear whether chronic GPER activation during menopause had an effect on… read more here.
Keywords: paneth; proliferation; chronic gper; gper activation ... See more keywords
G protein-coupled estrogen receptor-1: homology modeling approaches and application in screening new GPER-1 modulators
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1844059
Abstract: Abstract G protein-coupled receptors (GPCRs) belong to the largest family of protein targets comprising over 800 members in which at least 500 members are the therapeutic targets. Among the GPCRs, G protein-coupled estrogen receptor-1 (GPER-1)… read more here.
Keywords: homology; gper modulators; protein coupled; gper ... See more keywords
G protein-coupled estrogen receptor promotes acrosome reaction via regulation of Ca2 + signaling in mouse sperm
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac136
Abstract: Abstract G protein-coupled estrogen receptor (GPER), a seven-transmembrane G protein-coupled receptor, mediates the rapid pre-genomic signaling actions of estrogen and derivatives thereof. The expression of GPER is extensive in mammal male reproductive system. However, the… read more here.
Keywords: mouse sperm; mouse; gper; protein coupled ... See more keywords
Estrogen-independent regulation of myocardial autophagy by the G protein-coupled estrogen receptor 1
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733765
Abstract: Study Objective and Hypothesis: Macroautophagy is a process that degrades unwanted cellular components (cargo) to maintain tissue homeostasis. It operates basally but is upregulated under stressful conditions such as nutrient deprivation. Myocardial autophagy is cardioprotective,… read more here.
Keywords: physiology; estrogen independent; myocardial autophagy; gper ... See more keywords
Tanshinone IIA Inhibits Triple-Negative Breast Cancer Cells MDA-MB-231 via G Protein-Coupled Estrogen Receptor- (GPER-) Dependent Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Disease Markers"
DOI: 10.1155/2023/8371623
Abstract: Due to the lack of classic estrogen receptors, there has been a shortage of targeted therapy for triple-negative breast cancer (TNBC), resulting in a poor prognosis. However, the newly discovered G protein-coupled estrogen receptor (GPER)… read more here.
Keywords: mda 231; iia; tan iia; gper ... See more keywords
Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Health Perspectives"
DOI: 10.1289/ehp2387
Abstract: Background: Numerous studies have indicated the estrogenic effects of polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs (OH-PBDEs). However, the previous mechanistic studies focused on their estrogenic effects through genomic transcriptional activation of estrogen receptors. Objective:… read more here.
Keywords: gper pathways; coupled estrogen; protein coupled; gper ... See more keywords