Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25320
Abstract: Estrogens affect dopamine‐dependent diseases/behavior and have rapid effects on dopamine release and receptor availability in the nucleus accumbens (NAc). Low levels of nuclear estrogen receptor (ER) α and ERβ are seen in the NAc, which… read more here.
Keywords: localization; gper1; gabaergic neurons; core shell ... See more keywords
Attenuation of Hypertension and protection of vascular inflammation in hyperaldosteronism: GPER1 as potential therapeutic candidate when MR antagonist is less satisfying?
Sign Up to like & getrecommendations! Published in 2024 at "Endocrine"
DOI: 10.1007/s12020-024-04106-6
Abstract: Hyperaldosteronism is an endocrine disorder leading to persistent and severe hypertension. G protein-coupled estrogen receptor 1(GPER1) is regarded as a potential receptor of aldosterone (ALDO). This study aimed to investigate the effects of GPER1 on… read more here.
Keywords: vascular inflammation; gper1; attenuation hypertension; hypertension ... See more keywords
GPER1 in sand rat epididymis: Effects of seasonal variations, castration and efferent ducts ligation.
Sign Up to like & getrecommendations! Published in 2017 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2017.06.012
Abstract: Estrogen plays a crucial role in regulating epididymal function and development. Estrogen signaling is mediated via two main receptors essentially involved in the genomic regulating pathway: ERα and ERβ. Recent studies revealed the contribution of… read more here.
Keywords: sand; efferent ducts; estrogen; gper1 ... See more keywords
The novel estrogen receptor GPER1 decreases epilepsy severity and susceptivity in the hippocampus after status epilepticus
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134978
Abstract: The steroid hormone 17β-estradiol (estrogen) exerts neuroprotective effects in several types of neurological disorders including epilepsy. The novel G protein-coupled estrogen receptor 1 (GPER1), also called GPR30, mediates the non-genomic effects of 17β-estradiol. However, the… read more here.
Keywords: hippocampus; gper1; status epilepticus; severity ... See more keywords
G Protein-coupled Estrogen Receptor 1 Signaling Downregulates Epithelial Na Channel Activity in the Collecting Duct
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733110
Abstract: Hypertension is more prevalent in men than women. Sodium (Na+) homeostasis is critical for blood pressure control. Recent studies in our lab showed that activation of G-protein coupled estrogen receptor 1 (GPER1) in the renal… read more here.
Keywords: gper1; gper1 enac; physiology; activity ... See more keywords
G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-023-00763-x
Abstract: Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen dependence, suggest that estrogen… read more here.
Keywords: mtor signaling; akt mtor; gper1; ferroptosis ... See more keywords
The chronification mechanism of orofacial inflammatory pain: Facilitation by GPER1 and microglia in the rostral ventral medulla
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1078309
Abstract: Background Chronic orofacial pain is a common and incompletely defined clinical condition. The role of G protein-coupled estrogen receptor 1 (GPER1) as a new estrogen receptor in trunk and visceral pain regulation is well known.… read more here.
Keywords: rostral ventral; gper1; orofacial pain; pain ... See more keywords
Isoflavones Mediate Dendritogenesis Mainly through Estrogen Receptor α
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24109011
Abstract: The nuclear estrogen receptor (ER) and G-protein-coupled ER (GPER1) play a crucial role during brain development and are involved in dendrite and spine growth as well as synapse formation. Soybean isoflavones, such as genistein, daidzein,… read more here.
Keywords: estrogen receptor; isoflavone induced; gper1; dendritogenesis ... See more keywords