Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 having N-Glycans and Heparan Sulfates in Membranes
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2119
Abstract: The glypican family of cell-surface proteoglycans, anchored to the outer leaflet of eukaryotic cell membrane through a glycosylphosphatidylinosital (GPI) anchor, is involved in important cellular signaling pathways. Glypican-1 (Gpc1), the predominant heparan sulfate (HS) proteoglycan… read more here.
Keywords: dynamics interactions; interactions gpi; structure dynamics; gpi anchored ... See more keywords
A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02337-1
Abstract: Over 100 kinds of proteins are expressed as glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) on the cell surface in mammalian cells. GPI-APs possess unique properties in terms of their intracellular trafficking and association with lipid rafts. Although… read more here.
Keywords: cell library; gpi aps; gpi; anchored proteins ... See more keywords
Organization of GPI-anchored proteins at the cell surface and its physiopathological relevance
Sign Up to like & getrecommendations! Published in 2018 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2018.1485627
Abstract: Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a class of proteins attached to the extracellular leaflet of the plasma membrane via a post-translational modification, the glycolipid anchor. The presence of both glycolipid anchor and protein portion… read more here.
Keywords: organization gpi; gpi aps; gpi; anchored proteins ... See more keywords
Targeting the GPI biosynthetic pathway
Sign Up to like & getrecommendations! Published in 2018 at "Pathogens and Global Health"
DOI: 10.1080/20477724.2018.1442764
Abstract: Abstract The GPI (Glycosylphosphatidylinositol) biosynthetic pathway is a multistep conserved pathway in eukaryotes that culminates in the generation of GPI glycolipid which in turn anchors many proteins (GPI-APs) to the cell surface. In spite of… read more here.
Keywords: targeting gpi; biosynthetic pathway; pathway; gpi ... See more keywords
p24 Family Proteins Are Involved in Transport to the Plasma Membrane of GPI-Anchored Proteins in Plants.
Sign Up to like & getrecommendations! Published in 2020 at "Plant physiology"
DOI: 10.1104/pp.20.00880
Abstract: p24 proteins are a family of type-I membrane proteins that cycle between the endoplasmic reticulum (ER) and the Golgi apparatus via Coat Protein I (COPI)- and COPII-coated vesicles. These proteins have been proposed to function… read more here.
Keywords: anchored proteins; gpi anchored; plasma membrane; p24 ... See more keywords
Development of a novel PIG-A gene mutation assay based on a GPI-anchored fluorescent protein sensor
Sign Up to like & getrecommendations! Published in 2019 at "Genes and Environment"
DOI: 10.1186/s41021-019-0135-6
Abstract: BackgroundAccumulation of somatic mutations caused by both endogenous and exogenous exposures is a high risk for human health, in particular, cancer. Efficient detection of somatic mutations is crucial for risk assessment of different types of… read more here.
Keywords: pig; mutation assay; gpi; gene ... See more keywords
Endoplasmic Reticulum Export of GPI-Anchored Proteins
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DOI: 10.3390/ijms20143506
Abstract: Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory cargo… read more here.
Keywords: export; endoplasmic reticulum; gpi aps; anchored proteins ... See more keywords
Glycosylphosphatidylinositol Anchors from Galactomannan and GPI-Anchored Protein Are Synthesized by Distinct Pathways in Aspergillus fumigatus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fungi"
DOI: 10.3390/jof4010019
Abstract: Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall… read more here.
Keywords: gpi anchor; gpi aps; gpi; cell wall ... See more keywords