Clustering in the Golgi apparatus governs sorting and function of GPI‐APs in polarized epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13573
Abstract: Glycosylphosphatidylinositol‐anchored proteins (GPI‐APs) are lipid APs attached to the extracellular leaflet of the plasma membrane (PM) via a glycolipid anchor. GPI‐APs are commonly associated with cholesterol‐ and sphingolipid‐enriched membrane microdomains. These microdomains help regulating various… read more here.
Keywords: golgi apparatus; gpi aps; gpi; polarized epithelial ... See more keywords
Abnormal ER quality control of neural GPI-anchored proteins via dysfunction in ER export processing in the frontal cortex of elderly subjects with schizophrenia
Sign Up to like & getrecommendations! Published in 2019 at "Translational Psychiatry"
DOI: 10.1038/s41398-018-0359-4
Abstract: Abnormalities of posttranslational protein modifications (PTMs) have recently been implicated in the pathophysiology of schizophrenia. Glycosylphosphatidylinositols (GPIs) are a class of complex glycolipids, which anchor surface proteins and glycoproteins to the cell membrane. GPI attachment… read more here.
Keywords: protein; export; schizophrenia; gpi aps ... See more keywords
A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02337-1
Abstract: Over 100 kinds of proteins are expressed as glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) on the cell surface in mammalian cells. GPI-APs possess unique properties in terms of their intracellular trafficking and association with lipid rafts. Although… read more here.
Keywords: cell library; gpi aps; gpi; anchored proteins ... See more keywords
Active emulsions in living cell membranes driven by contractile stresses and transbilayer coupling
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123056119
Abstract: The spatiotemporal organisation of proteins and lipids on the cell surface has direct functional consequences for signaling, sorting and endocytosis. Earlier studies have shown that multiple types of membrane proteins including transmembrane proteins that have… read more here.
Keywords: contractile stresses; emulsions living; transbilayer coupling; active emulsions ... See more keywords
Organization of GPI-anchored proteins at the cell surface and its physiopathological relevance
Sign Up to like & getrecommendations! Published in 2018 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2018.1485627
Abstract: Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a class of proteins attached to the extracellular leaflet of the plasma membrane via a post-translational modification, the glycolipid anchor. The presence of both glycolipid anchor and protein portion… read more here.
Keywords: organization gpi; gpi aps; gpi; anchored proteins ... See more keywords
Endoplasmic Reticulum Export of GPI-Anchored Proteins
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20143506
Abstract: Protein export from the endoplasmic reticulum (ER) is an essential process in all eukaryotes driven by the cytosolic coat complex COPII, which forms vesicles at ER exit sites for transport of correctly assembled secretory cargo… read more here.
Keywords: export; endoplasmic reticulum; gpi aps; anchored proteins ... See more keywords
Biological Role of the Intercellular Transfer of Glycosylphosphatidylinositol-Anchored Proteins: Stimulation of Lipid and Glycogen Synthesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137418
Abstract: Glycosylphosphatidylinositol-anchored proteins (GPI-APs), which are anchored at the outer leaflet of plasma membranes (PM) only by a carboxy-terminal GPI glycolipid, are known to fulfill multiple enzymic and receptor functions at the cell surface. Previous studies… read more here.
Keywords: full length; gpi; transfer; length gpi ... See more keywords
Transfer of Proteins from Cultured Human Adipose to Blood Cells and Induction of Anabolic Phenotype Are Controlled by Serum, Insulin and Sulfonylurea Drugs
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054825
Abstract: Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are anchored at the outer leaflet of eukaryotic plasma membranes (PMs) only by carboxy-terminal covalently coupled GPI. GPI-APs are known to be released from the surface of donor cells in response to… read more here.
Keywords: gpi; transfer; glycogen synthesis; gpi aps ... See more keywords
Glycosylphosphatidylinositol Anchors from Galactomannan and GPI-Anchored Protein Are Synthesized by Distinct Pathways in Aspergillus fumigatus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fungi"
DOI: 10.3390/jof4010019
Abstract: Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane. In fungi, a number of GPI-anchored proteins (GPI-APs) are involved in the remodeling of the cell wall… read more here.
Keywords: gpi anchor; gpi aps; gpi; cell wall ... See more keywords