Neutrophil infiltration to the brain is platelet‐dependent, and is reversed by blockade of platelet GPIbα
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1111/imm.12892
Abstract: Neutrophils are key components of the innate immune response, providing host defence against infection and being recruited to non‐microbial injury sites. Platelets act as a trigger for neutrophil extravasation to inflammatory sites but mechanisms and… read more here.
Keywords: neutrophil infiltration; infiltration brain; gpib; brain ... See more keywords
Extracellular signal‐regulated kinase 5 associates with casein kinase II to regulate GPIb‐IX‐mediated platelet activation via the PTEN/PI3K/Akt pathway
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13755
Abstract: Essentials The mechanisms of extracellular signal‐regulated kinase 5 (ERK5) in GPIb‐IX signaling are unclear. Function of ERK5 in GPIb‐IX was tested using aggregation, western blotting, and mass spectrometry. The protein interacting with ERK5 in human… read more here.
Keywords: kinase; extracellular signal; regulated kinase; gpib ... See more keywords
Fast clearance of platelets in a commonly used mouse model for GPIbα is impeded by an anti‐GPIbβ antibody derivative
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15702
Abstract: Glycoprotein (GP)Ibα plays a critical role in regulating platelet clearance. Recently, we identified the mechanosensory domain (MSD) in GPIbα and reported evidence to suggest that unfolding of the GPIbα MSD induces exposure of the Trigger… read more here.
Keywords: clearance; commonly used; gpib antibody; gpib ... See more keywords
Thrombocytopathy leading to impaired in vivo haemostasis and thrombosis in platelet type von Willebrand disease.
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis and haemostasis"
DOI: 10.1160/th16-04-0317
Abstract: Platelet defects due to hyper-responsive GPIbα causing enhanced VWF interaction, counter-intuitively result in bleeding rather than thrombosis. The historical explanation of platelet/VWF clearance fails to explain mechanisms of impaired haemostasis particularly in light of reported… read more here.
Keywords: thrombosis; haemostasis; gpib; impaired vivo ... See more keywords
14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2017-09-742650
Abstract: Members of the 14-3-3 family of proteins function as adapters/modulators that recognize phosphoserine/phosphothreonine-based binding motifs in many intracellular proteins and play fundamental roles in signal transduction pathways of eukaryotic cells. In platelets, 14-3-3 plays a… read more here.
Keywords: proteins platelet; platelet biology; biology glycoprotein; glycoprotein signaling ... See more keywords
Binding of Gpibα to VWF A2 Domain Alters Mechanical Unraveling of the A2 Domain
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143275
Abstract: Background: Von Willebrand factor (VWF), is a large, multimeric plasma glycoprotein that plays a critical role in hemostasis. VWF is synthesized and secreted as ultra large (UL) multimers that contain up to 100 protomers. If… read more here.
Keywords: gpib vwf; gpib; force; extension ... See more keywords
S100A8/A9 drives the formation of procoagulant platelets through GPIbα
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014966
Abstract: Abstract S100A8/A9, also known as “calprotectin” or “MRP8/14,” is an alarmin primarily secreted by activated myeloid cells with antimicrobial, proinflammatory, and prothrombotic properties. Increased plasma levels of S100A8/A9 in thrombo-inflammatory diseases are associated with thrombotic… read more here.
Keywords: s100a8 drives; s100a8; procoagulant platelets; gpib ... See more keywords
A p.Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2021005463
Abstract: Gain-of-function (GoF) variants in GP1BA cause platelet-type von Willebrand disease (PT-VWD), a rare inherited autosomal dominant bleeding disorder characterized by enhanced platelet GPIbα-von Willebrand factor (VWF) interaction and thrombocytopenia. To date, only 6 variants causing… read more here.
Keywords: disulfide loop; terminal disulfide; gpib; affinity vwf ... See more keywords
Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2019.240440
Abstract: During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice, we report that the… read more here.
Keywords: platelet clearance; desialylation glycans; gpib; clearance ... See more keywords
The Glycoprotein (GP)Ib-IX-V Complex on Platelets: GPIbα Protein Expression Is Reduced in HeartMate 3 Patients with Bleeding Complications within the First 3 Months
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065639
Abstract: Non-surgical bleeding (NSB) remains the most critical complication in patients under left ventricular assist device (LVAD) support. It is well known that blood exposed to high shear stress results in platelet dysfunction. Compared to patients… read more here.
Keywords: protein expression; gpib; expression; bleeder ... See more keywords