Investigation of redox modifications of platelet integrin GPIIb-IIIa in diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.102
Abstract: Diabetes is a global health problem, affecting 382 million people worldwide. Critically, up to 70% of deaths from diabetes are due to the development of occlusive blood clots (thrombosis), leading to heart attack and stroke.… read more here.
Keywords: iiia diabetes; gpiib; integrin gpiib; gpiib iiia ... See more keywords
Using flow cytometry to monitor glycoprotein IIb-IIIa activation
Sign Up to like & getrecommendations! Published in 2018 at "Platelets"
DOI: 10.1080/09537104.2018.1478073
Abstract: Abstract Platelet-to-platelet aggregation is critical to the formation of hemostatic thrombi which limit bleeding following vascular injury and also contributes to obstructive thrombi in acute myocardial infarction, stroke, or other thrombotic diseases. Platelet aggregation is… read more here.
Keywords: iiia; iiia activation; flow cytometry; gpiib iiia ... See more keywords
Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as a therapeutic target in COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022008666
Abstract: Thromboembolic events are frequent and life-threating complications of COVID-19, but are also observed in patients with sepsis. Disseminated thrombosis can occur despite anticoagulation, suggesting that platelets play a direct, but yet incompletely understood role. Several… read more here.
Keywords: sepsis; covid; granule release; gpiib iiia ... See more keywords